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    ZSWIM8 zinc finger SWIM-type containing 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 533041, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ZSWIM8provided by VGNC
    Official Full Name
    zinc finger SWIM-type containing 8provided by VGNC
    Primary source
    VGNC:VGNC:37388
    See related
    BGD:BT22220; Ensembl:ENSBTAG00000012657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ZSWIM8 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (29682472..29696485)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104969719 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene calcium/calmodulin dependent protein kinase II gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0913, MGC159954

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger SWIM domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371877.1 → NP_001358806.1  zinc finger SWIM domain-containing protein 8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      NKLS02000028
      UniProtKB/TrEMBL
      A0AAA9THX6
      Conserved Domains (2) summary
      PHA03247
      Location:1530 → 1895
      PHA03247; large tegument protein UL36; Provisional
      pfam03546
      Location:1019 → 1161
      Treacle; Treacher Collins syndrome protein Treacle

    2. NM_001371878.1 → NP_001358807.1  zinc finger SWIM domain-containing protein 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      NKLS02000028
      UniProtKB/TrEMBL
      A0AAA9THX6
      Conserved Domains (3) summary
      PHA03247
      Location:1530 → 1887
      PHA03247; large tegument protein UL36; Provisional
      pfam03154
      Location:1492 → 1654
      Atrophin-1; Atrophin-1 family
      pfam03546
      Location:1019 → 1161
      Treacle; Treacher Collins syndrome protein Treacle

    3. NM_001371879.1 → NP_001358808.1  zinc finger SWIM domain-containing protein 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      NKLS02000028
      UniProtKB/TrEMBL
      A0AAA9THX6, E1BCX3
      Related
      ENSBTAP00070037368.1, ENSBTAT00070062512.1
      Conserved Domains (4) summary
      PHA03307
      Location:960 → 1169
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK14951
      Location:1537 → 1666
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      pfam07271
      Location:1038 → 1139
      Cytadhesin_P30; Cytadhesin P30/P32
      cl27046
      Location:1510 → 1598
      CopB; Copper resistance protein B precursor (CopB)

    4. NM_001371880.1 → NP_001358809.1  zinc finger SWIM domain-containing protein 8 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      NKLS02000028
      UniProtKB/TrEMBL
      A0AAA9THX6
      Conserved Domains (2) summary
      PRK14951
      Location:1537 → 1658
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      pfam03546
      Location:1019 → 1161
      Treacle; Treacher Collins syndrome protein Treacle

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29682472..29696485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001102149.1: Suppressed sequence

      Description
      NM_001102149.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7E305.1 GenPept UniProtKB/Swiss-Prot:A7E305

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.