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    SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 540904, updated on 1-Jan-2025

    Summary

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    Official Symbol
    SMARCA2provided by VGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2provided by VGNC
    Primary source
    VGNC:VGNC:34986
    See related
    Ensembl:ENSBTAG00000007494
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SMARCA2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (42369774..42549438, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345951 Neighboring gene disks large-associated protein 1-like Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene transfer RNA cysteine (anticodon GCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148877

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable global transcription activator SNF2L2
    Names
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099115.2 → NP_001092585.1  probable global transcription activator SNF2L2

      See identical proteins and their annotated locations for NP_001092585.1

      Status: PROVISIONAL

      Source sequence(s)
      BC142521
      UniProtKB/TrEMBL
      A5PKK5
      Related
      ENSBTAP00000035551.3, ENSBTAT00000035681.5
      Conserved Domains (9) summary
      cd05516
      Location:1364 → 1470
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:418 → 490
      HSA; domain in helicases and associated with SANT domains
      pfam07533
      Location:572 → 612
      BRK; BRK domain
      pfam08880
      Location:172 → 206
      QLQ; QLQ
      pfam09606
      Location:44 → 326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1241 → 1308
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:1315 → 1377
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl25548
      Location:298 → 505
      DUF4670; Domain of unknown function (DUF4670)
      cl26465
      Location:702 → 1184
      SNF2_N; SNF2 family N-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42369774..42549438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015472482.3 → XP_015327968.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A5PKK5
      Conserved Domains (9) summary
      cd05516
      Location:1364 → 1470
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:418 → 490
      HSA; domain in helicases and associated with SANT domains
      pfam07533
      Location:572 → 612
      BRK; BRK domain
      pfam08880
      Location:172 → 206
      QLQ; QLQ
      pfam09606
      Location:44 → 326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1241 → 1308
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:1315 → 1377
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl25548
      Location:298 → 505
      DUF4670; Domain of unknown function (DUF4670)
      cl26465
      Location:702 → 1184
      SNF2_N; SNF2 family N-terminal domain

    2. XM_005209984.5 → XP_005210041.1  probable global transcription activator SNF2L2 isoform X1

      See identical proteins and their annotated locations for XP_005210041.1

      UniProtKB/TrEMBL
      A0A3Q1LRS4
      Related
      ENSBTAP00000057766.2, ENSBTAT00000083498.2
      Conserved Domains (9) summary
      cd05516
      Location:1364 → 1488
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:418 → 490
      HSA; domain in helicases and associated with SANT domains
      pfam07533
      Location:572 → 612
      BRK; BRK domain
      pfam08880
      Location:172 → 206
      QLQ; QLQ
      pfam09606
      Location:44 → 326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1241 → 1308
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:1315 → 1401
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl25548
      Location:298 → 505
      DUF4670; Domain of unknown function (DUF4670)
      cl26465
      Location:702 → 1184
      SNF2_N; SNF2 family N-terminal domain

    3. XM_059889213.1 → XP_059745196.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A5PKK5

    4. XM_059889211.1 → XP_059745194.1  probable global transcription activator SNF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LRS4

    5. XM_024995911.2 → XP_024851679.1  probable global transcription activator SNF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LRS4
      Conserved Domains (9) summary
      cd05516
      Location:1364 → 1488
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:418 → 490
      HSA; domain in helicases and associated with SANT domains
      pfam07533
      Location:572 → 612
      BRK; BRK domain
      pfam08880
      Location:172 → 206
      QLQ; QLQ
      pfam09606
      Location:44 → 326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1241 → 1308
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:1315 → 1401
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl25548
      Location:298 → 505
      DUF4670; Domain of unknown function (DUF4670)
      cl26465
      Location:702 → 1184
      SNF2_N; SNF2 family N-terminal domain

    6. XM_059889210.1 → XP_059745193.1  probable global transcription activator SNF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LRS4

    7. XM_059889212.1 → XP_059745195.1  probable global transcription activator SNF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LRS4

    8. XM_024995912.2 → XP_024851680.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A5PKK5
      Conserved Domains (9) summary
      cd05516
      Location:1364 → 1470
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:418 → 490
      HSA; domain in helicases and associated with SANT domains
      pfam07533
      Location:572 → 612
      BRK; BRK domain
      pfam08880
      Location:172 → 206
      QLQ; QLQ
      pfam09606
      Location:44 → 326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1241 → 1308
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:1315 → 1377
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl25548
      Location:298 → 505
      DUF4670; Domain of unknown function (DUF4670)
      cl26465
      Location:702 → 1184
      SNF2_N; SNF2 family N-terminal domain

    9. XM_005209983.5 → XP_005210040.1  probable global transcription activator SNF2L2 isoform X1

      See identical proteins and their annotated locations for XP_005210040.1

      UniProtKB/TrEMBL
      A0A3Q1LRS4
      Conserved Domains (9) summary
      cd05516
      Location:1364 → 1488
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:418 → 490
      HSA; domain in helicases and associated with SANT domains
      pfam07533
      Location:572 → 612
      BRK; BRK domain
      pfam08880
      Location:172 → 206
      QLQ; QLQ
      pfam09606
      Location:44 → 326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1241 → 1308
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:1315 → 1401
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl25548
      Location:298 → 505
      DUF4670; Domain of unknown function (DUF4670)
      cl26465
      Location:702 → 1184
      SNF2_N; SNF2 family N-terminal domain

    10. XM_010807855.4 → XP_010806157.1  probable global transcription activator SNF2L2 isoform X4

      See identical proteins and their annotated locations for XP_010806157.1

      Related
      ENSBTAP00000073683.2, ENSBTAT00000086834.2
      Conserved Domains (2) summary
      cd05516
      Location:86 → 192
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:37 → 99
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    11. XM_015472483.3 → XP_015327969.1  probable global transcription activator SNF2L2 isoform X3

      Conserved Domains (7) summary
      smart00573
      Location:418 → 490
      HSA; domain in helicases and associated with SANT domains
      pfam07533
      Location:572 → 612
      BRK; BRK domain
      pfam08880
      Location:172 → 206
      QLQ; QLQ
      pfam09606
      Location:44 → 326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1241 → 1308
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl25548
      Location:298 → 533
      DUF4670; Domain of unknown function (DUF4670)
      cl26465
      Location:702 → 1184
      SNF2_N; SNF2 family N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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