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    ARHGDIA Rho GDP dissociation inhibitor alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 338054, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ARHGDIAprovided by VGNC
    Official Full Name
    Rho GDP dissociation inhibitor alphaprovided by VGNC
    Primary source
    VGNC:VGNC:26101
    See related
    BGD:BT10632
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGDIA in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (51024488..51028503)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 11 Neighboring gene neuropeptide B Neighboring gene Aly/REF export factor Neighboring gene proteasome assembly chaperone 3-like Neighboring gene prolyl 4-hydroxylase subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Fukumoto Y, et al. Oncogene, 1990 Sep. PMID 2120668
    2. Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Oesterlin LK, et al. Proc Natl Acad Sci U S A, 2012 Apr 10. PMID 22411835, Free PMC Article
    3. Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. Maddala R, et al. Dev Biol, 2008 Mar 1. PMID 18234179, Free PMC Article
    4. Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved. Wei L, et al. FASEB J, 2004 May. PMID 15033930
    5. C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Gosser YQ, et al. Nature, 1997 Jun 19. PMID 9194563

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effective GDI displacement that is observed is caused by inhibition of reformation of Rab:GDI complexes.
      Title: Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor.
    2. Rho GDP association inhibitor (GDI) alpha- mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival.
      Title: Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival.
    3. that inhibition of Ca2+ channel activity by overexpression of Rho GDI-alpha is mediated by inhibition of RhoA in cardiac myocytes
      Title: RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes.
    4. Increased expression of bovine Rho GDIalpha led to electrophysiological alterations that resulted in atrial arrhythmias and AV conduction abnormalities in transgenic mice, whereas ventricular contractile function was largely preserved.
      Title: Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Rho GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GDP-dissociation inhibitor 1
    Names
    Rho GDP dissociation inhibitor (GDI) alpha
    rho GDI 1
    rho-GDI alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176650.3 → NP_788823.1  rho GDP-dissociation inhibitor 1

      See identical proteins and their annotated locations for NP_788823.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103465
      UniProtKB/Swiss-Prot
      P19803, Q3ZBA9
      Conserved Domains (1) summary
      pfam02115
      Location:11 → 201
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51024488..51028503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059877758.1 → XP_059733741.1  rho GDP-dissociation inhibitor 1 isoform X1

      UniProtKB/Swiss-Prot
      P19803, Q3ZBA9

    2. XM_005221011.5 → XP_005221068.2  rho GDP-dissociation inhibitor 1 isoform X1

      See identical proteins and their annotated locations for XP_005221068.2

      UniProtKB/Swiss-Prot
      P19803, Q3ZBA9
      Conserved Domains (1) summary
      pfam02115
      Location:11 → 201
      Rho_GDI; RHO protein GDP dissociation inhibitor

    3. XM_059877756.1 → XP_059733739.1  rho GDP-dissociation inhibitor 1 isoform X2

      UniProtKB/TrEMBL
      Q58DT6

    4. XM_059877757.1 → XP_059733740.1  rho GDP-dissociation inhibitor 1 isoform X2

      UniProtKB/TrEMBL
      Q58DT6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19803.3 GenPept UniProtKB/Swiss-Prot:P19803

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials