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    FAT1 FAT atypical cadherin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 508251, updated on 29-Jan-2025

    Summary

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    Official Symbol
    FAT1provided by VGNC
    Official Full Name
    FAT atypical cadherin 1provided by VGNC
    Primary source
    VGNC:VGNC:52771
    See related
    BGD:BT13826; Ensembl:ENSBTAG00000020657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FAT
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See FAT1 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (16420184..16546113, complement)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344050 Neighboring gene melatonin receptor 1A Neighboring gene small ribosomal subunit protein eS28-like Neighboring gene uncharacterized LOC101905556

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protocadherin Fat 1
    Names
    FAT tumor suppressor homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192992.2 → NP_001179921.2  protocadherin Fat 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CO875056, DAAA02060206, DAAA02060207, DAAA02060208, DY177990
      UniProtKB/TrEMBL
      E1BKL9
      Related
      ENSBTAP00070017297.1, ENSBTAT00070028329.1
      Conserved Domains (5) summary
      cd11304
      Location:3234 → 3331
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:3854 → 3985
      LamG; Laminin G domain
      cd00054
      Location:4127 → 4163
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:4093 → 4123
      EGF; EGF-like domain
      cl09101
      Location:277 → 356
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      16420184..16546113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010820249.4 → XP_010818551.2  protocadherin Fat 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M5W5, E1BKL9
      Related
      ENSBTAP00070017313.1, ENSBTAT00070028352.1
      Conserved Domains (5) summary
      cd11304
      Location:3234 → 3331
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:3854 → 3985
      LamG; Laminin G domain
      cd00054
      Location:4127 → 4163
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:4093 → 4123
      EGF; EGF-like domain
      cl09101
      Location:277 → 356
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    2. XM_059882182.1 → XP_059738165.1  protocadherin Fat 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M5W5, E1BKL9

    3. XM_059882180.1 → XP_059738163.1  protocadherin Fat 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M5W5, E1BKL9

    4. XM_059882181.1 → XP_059738164.1  protocadherin Fat 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M5W5, E1BKL9

    5. XM_059882183.1 → XP_059738166.1  protocadherin Fat 1 isoform X2

      UniProtKB/TrEMBL
      E1BKL9

    RNA

    1. XR_815911.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials