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    PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 507414, updated on 29-Jan-2025

    Summary

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    Official Symbol
    PIK3R4provided by VGNC
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 4provided by VGNC
    Primary source
    VGNC:VGNC:32895
    See related
    BGD:BT16549; Ensembl:ENSBTAG00000020787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3R4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (151476132..151562596)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346086 Neighboring gene uncharacterized LOC132346085 Neighboring gene collagen type VI alpha 6 chain Neighboring gene collagen type VI alpha 5 chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus-vacuole junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoinositide 3-kinase regulatory subunit 4
    NP_001093784.1
    XP_005202187.1
    XP_024856833.1
    XP_059730433.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100314.2 → NP_001093784.1  phosphoinositide 3-kinase regulatory subunit 4

      See identical proteins and their annotated locations for NP_001093784.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148105
      UniProtKB/TrEMBL
      A6QLW1
      Conserved Domains (5) summary
      smart00320
      Location:1327 → 1358
      WD40; WD40 repeats
      cd13980
      Location:25 → 320
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:539 → 566
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:997 → 1040
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:985 → 1269
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      151476132..151562596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202130.4 → XP_005202187.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LLF0
      Related
      ENSBTAP00070035486.1, ENSBTAT00070059803.1
      Conserved Domains (7) summary
      COG2319
      Location:983 → 1314
      WD40; WD40 repeat [General function prediction only]
      cd13980
      Location:25 → 320
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      pfam00069
      Location:26 → 309
      Pkinase; Protein kinase domain
      pfam07539
      Location:317 → 448
      DRIM; Down-regulated in metastasis
      sd00044
      Location:539 → 566
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:997 → 1040
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:985 → 1314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_025001065.2 → XP_024856833.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X2

      Conserved Domains (5) summary
      smart00320
      Location:1269 → 1300
      WD40; WD40 repeats
      cd13980
      Location:25 → 320
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:379 → 404
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:939 → 982
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:927 → 1211
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_059874450.1 → XP_059730433.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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