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    NFE2L2 NFE2 like bZIP transcription factor 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 497024, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NFE2L2provided by VGNC
    Official Full Name
    NFE2 like bZIP transcription factor 2provided by VGNC
    Primary source
    VGNC:VGNC:32036
    See related
    BGD:BT24333; Ensembl:ENSBTAG00000019255
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NRF2
    Orthologs
    human mouse all
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    Genomic context

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    See NFE2L2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (19617016..19649649)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase type IVA 1-like Neighboring gene uncharacterized LOC132342952 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene microRNA mir-4444 Neighboring gene uncharacterized LOC132342955

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling. Wang Y, et al. Int J Mol Sci, 2019 Dec 5. PMID 31817362, Free PMC Article
    2. Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function. Khadrawy O, et al. Int J Mol Sci, 2019 Apr 2. PMID 30986945, Free PMC Article
    3. Bovine embryo survival under oxidative-stress conditions is associated with activity of the NRF2-mediated oxidative-stress-response pathway. Amin A, et al. Mol Reprod Dev, 2014 Jun. PMID 25057524
    4. Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation. Gessner DK, et al. J Dairy Sci, 2013 Feb. PMID 23245956
    5. Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells†. Murata H, et al. Biol Reprod, 2021 Nov 15. PMID 34296252

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
      Title: Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
    2. Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cellsdagger.
      Title: Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells†.
    3. These results demonstrate that Astragaloside IV treatment effectively protects against H2O2-induced oxidative damage in calf small intestine epithelial cells through the activation of the NFE2L2-antioxidant response element signaling pathway.
      Title: Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
    4. this study highlighted the involvement of miR-153, miR-28 and miR-708 in regulatory network of Nrf2 mediated antioxidant system in bovine granulosa cells function.
      Title: Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function.
    5. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 within these cells.
      Title: Immunohistochemical expression of nuclear factor erythroid-2-related factor 2 and heme oxygenase 1 in normal bovine lung and bovine lung infected with Mannheimia haemolytica.
    6. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
      Title: Bovine embryo survival under oxidative-stress conditions is associated with activity of the NRF2-mediated oxidative-stress-response pathway.
    7. expression of target genes in liver in transition period and stages of lactation
      Title: Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation.
    8. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products
      Title: Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor erythroid 2-related factor 2
    Names
    NF-E2-related factor 2
    NFE2-related factor 2
    nuclear factor (erythroid-derived 2)-like 2
    nuclear factor, erythroid 2 like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011678.2 → NP_001011678.2  nuclear factor erythroid 2-related factor 2

      See identical proteins and their annotated locations for NP_001011678.2

      Status: PROVISIONAL

      Source sequence(s)
      BT030494
      UniProtKB/Swiss-Prot
      Q3T0S8, Q5NUA6
      UniProtKB/TrEMBL
      A5D975
      Conserved Domains (2) summary
      cd14720
      Location:496 → 563
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
      pfam06886
      Location:34 → 74
      TPX2; Targeting protein for Xklp2 (TPX2)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19617016..19649649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999476.2 → XP_024855244.1  nuclear factor erythroid 2-related factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LRK0
      Conserved Domains (1) summary
      cd14720
      Location:480 → 547
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    2. XM_005202312.5 → XP_005202369.1  nuclear factor erythroid 2-related factor 2 isoform X1

      See identical proteins and their annotated locations for XP_005202369.1

      UniProtKB/TrEMBL
      A0A3Q1LRK0
      Conserved Domains (1) summary
      cd14720
      Location:480 → 547
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    3. XM_024999479.2 → XP_024855247.1  nuclear factor erythroid 2-related factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LRK0
      Related
      ENSBTAP00070001222.1, ENSBTAT00070002237.1
      Conserved Domains (1) summary
      cd14720
      Location:480 → 547
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    4. XM_005202311.5 → XP_005202368.1  nuclear factor erythroid 2-related factor 2 isoform X1

      See identical proteins and their annotated locations for XP_005202368.1

      UniProtKB/TrEMBL
      A0A3Q1LRK0
      Related
      ENSBTAP00070001225.1, ENSBTAT00070002243.1
      Conserved Domains (1) summary
      cd14720
      Location:480 → 547
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    5. XM_005202314.5 → XP_005202371.1  nuclear factor erythroid 2-related factor 2 isoform X1

      See identical proteins and their annotated locations for XP_005202371.1

      UniProtKB/TrEMBL
      A0A3Q1LRK0
      Conserved Domains (1) summary
      cd14720
      Location:480 → 547
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NUA6.2 GenPept UniProtKB/Swiss-Prot:Q5NUA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials