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    ADGRL2 adhesion G protein-coupled receptor L2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281278, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ADGRL2provided by VGNC
    Official Full Name
    adhesion G protein-coupled receptor L2provided by VGNC
    Primary source
    VGNC:VGNC:53846
    See related
    Ensembl:ENSBTAG00000012305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LEC2; LPHN2
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ADGRL2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (62437260..63147752, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene ATP synthase subunit epsilon, mitochondrial-like Neighboring gene transfer RNA cysteine (anticodon ACA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. Matsushita H, et al. FEBS Lett, 1999 Jan 29. PMID 10025961
    2. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. Lelianova VG, et al. J Biol Chem, 1997 Aug 22. PMID 9261169
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L2
    Names
    CIRL-2
    calcium-independent alpha-latrotoxin receptor 2
    latrophilin-2
    lectomedin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181013.1 → NP_851356.1  adhesion G protein-coupled receptor L2 precursor

      See identical proteins and their annotated locations for NP_851356.1

      Status: PROVISIONAL

      Source sequence(s)
      AF111084
      UniProtKB/Swiss-Prot
      O97805, O97807, O97809, O97810, O97811, O97812, O97813, O97814, O97815, O97816, O97817
      UniProtKB/TrEMBL
      A0A3Q1MQ77
      Related
      ENSBTAP00000073734.2, ENSBTAT00000067330.2
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam00002
      Location:849 → 1099
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1119 → 1478
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:543 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      62437260..63147752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97817.1 GenPept UniProtKB/Swiss-Prot:O97817

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