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    ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 505940, updated on 27-Dec-2024

    Summary

    Official Symbol
    ARHGEF2provided by VGNC
    Official Full Name
    Rho/Rac guanine nucleotide exchange factor 2provided by VGNC
    Primary source
    VGNC:VGNC:26111
    See related
    BGD:BT13897; Ensembl:ENSBTAG00000000113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ARHGEF2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (14764700..14813371)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112445859 Neighboring gene signal sequence receptor subunit 2 Neighboring gene relaxin family peptide/INSL5 receptor 4 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC152523

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 2
    Names
    Rho/Rac guanine nucleotide exchange factor (GEF) 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098881.3NP_001092351.2  rho guanine nucleotide exchange factor 2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000003
      UniProtKB/TrEMBL
      A0A3Q1M9W2, F1N1F7
      Related
      ENSBTAP00000033820.4, ENSBTAT00000033917.5
      Conserved Domains (4) summary
      cd00029
      Location:4085
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:236430
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:470585
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:473571
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14764700..14813371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010802880.4XP_010801182.1  rho guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M8D9, A0AAA9SQC6
      Related
      ENSBTAP00000088538.1, ENSBTAT00000100504.1
      Conserved Domains (4) summary
      cd00029
      Location:247292
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:443637
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:677792
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:680778
      PH; PH domain
    2. XM_059882616.1XP_059738599.1  rho guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M8D9
    3. XM_024986243.2XP_024842011.2  rho guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M8D9
      Related
      ENSBTAP00000070165.2, ENSBTAT00000071999.2
    4. XM_059882630.1XP_059738613.1  rho guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1M8D9
    5. XM_005203665.5XP_005203722.1  rho guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LNZ7, A0A3Q1M9W2
      Related
      ENSBTAP00000058733.2, ENSBTAT00000074754.2
      Conserved Domains (4) summary
      cd00029
      Location:2570
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:221415
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:455570
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:458556
      PH; PH domain
    6. XM_024986265.2XP_024842033.1  rho guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1M9W2
      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:209403
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:443558
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:774835
      DUF390; Protein of unknown function (DUF390)
    7. XM_015462085.3XP_015317571.1  rho guanine nucleotide exchange factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1M9W2
      Conserved Domains (4) summary
      cd00029
      Location:4186
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:237431
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:471586
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:474572
      PH; PH domain
    8. XM_005203666.5XP_005203723.1  rho guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1M9W2
      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:209403
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:443558
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:774835
      DUF390; Protein of unknown function (DUF390)
    9. XM_005203664.5XP_005203721.5  rho guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M9W2