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    DEPTOR DEP domain containing MTOR interacting protein [ Bos taurus (domestic cattle) ]

    Gene ID: 617606, updated on 30-Jan-2025

    Summary

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    Official Symbol
    DEPTORprovided by VGNC
    Official Full Name
    DEP domain containing MTOR interacting proteinprovided by VGNC
    Primary source
    VGNC:VGNC:28008
    See related
    EnsemblRapid:ENSBTAG00070018810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DEPDC6
    Orthologs
    human mouse all
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    Genomic context

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    See DEPTOR in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (81286795..81453257)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene keratin-associated protein 10-7 Neighboring gene U6 spliceosomal RNA Neighboring gene collagen type XIV alpha 1 chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC159504

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC2 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DEP domain-containing mTOR-interacting protein
    Names
    DEP domain containing 6
    Rap guanine nucleotide exchange factor (GEF) 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102312.1 → NP_001095782.1  DEP domain-containing mTOR-interacting protein

      See identical proteins and their annotated locations for NP_001095782.1

      Status: PROVISIONAL

      Source sequence(s)
      BC149596
      UniProtKB/TrEMBL
      A0AAA9S3V2, A6QQ17, F6RLE1
      Related
      ENSBTAP00070025384.1, ENSBTAT00070042509.1
      Conserved Domains (3) summary
      cd04441
      Location:122 → 206
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:25 → 106
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cl00117
      Location:328 → 356
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      81286795..81453257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025001757.2 → XP_024857525.1  DEP domain-containing mTOR-interacting protein isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MZX3
      Related
      ENSBTAP00070025468.1, ENSBTAT00070042654.1
      Conserved Domains (2) summary
      cd04441
      Location:151 → 235
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:54 → 135
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

    2. XM_025001756.2 → XP_024857524.1  DEP domain-containing mTOR-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0AAA9S3V2
      Related
      ENSBTAP00070025449.1, ENSBTAT00070042625.1
      Conserved Domains (3) summary
      cd00992
      Location:357 → 421
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04441
      Location:151 → 235
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:54 → 135
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

    3. XM_025001760.2 → XP_024857528.1  DEP domain-containing mTOR-interacting protein isoform X5

      UniProtKB/TrEMBL
      A0A3Q1M184
      Related
      ENSBTAP00070025400.1, ENSBTAT00070042536.1
      Conserved Domains (3) summary
      cd04441
      Location:151 → 235
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:54 → 135
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cl00117
      Location:357 → 386
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    4. XM_025001759.2 → XP_024857527.1  DEP domain-containing mTOR-interacting protein isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M184, A0A3Q1MZX3
      Conserved Domains (2) summary
      cd04441
      Location:151 → 235
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:54 → 135
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

    5. XM_025001758.2 → XP_024857526.1  DEP domain-containing mTOR-interacting protein isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MZX3
      Related
      ENSBTAP00070025389.1, ENSBTAT00070042518.1
      Conserved Domains (2) summary
      cd04441
      Location:151 → 235
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:54 → 135
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

    6. XM_025001761.2 → XP_024857529.1  DEP domain-containing mTOR-interacting protein isoform X6

      UniProtKB/TrEMBL
      A0AAA9S3V2
      Conserved Domains (3) summary
      cd00992
      Location:308 → 372
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04441
      Location:102 → 186
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cl02442
      Location:11 → 86
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

    RNA

    1. XR_003038042.2 RNA Sequence

    2. XR_009490380.1 RNA Sequence

    3. XR_009490381.1 RNA Sequence

    4. XR_009490379.1 RNA Sequence

    5. XR_009490378.1 RNA Sequence

    6. XR_003038043.2 RNA Sequence

    7. XR_003038044.2 RNA Sequence

    8. XR_003038046.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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