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    VDAC2 voltage dependent anion channel 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282120, updated on 27-Dec-2024

    Summary

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    Official Symbol
    VDAC2provided by VGNC
    Official Full Name
    voltage dependent anion channel 2provided by VGNC
    Primary source
    VGNC:VGNC:36783
    See related
    BGD:BT27754; Ensembl:ENSBTAG00000012975
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See VDAC2 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (30970396..30984667)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 8 Neighboring gene dual specificity phosphatase 13 Neighboring gene dual specificity phosphatase 13A Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase subunit C-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional characterization of VDAC2 purified from mammal spermatozoa. Menzel VA, et al. Biosci Rep, 2009 Jul 22. PMID 18976238
    2. Localisation and function of voltage-dependent anion channels (VDAC) in bovine spermatozoa. Triphan X, et al. Pflugers Arch, 2008 Jan. PMID 17647012
    3. VDAC2 (porin-2) expression pattern and localization in the bovine testis. Hinsch KD, et al. Biochim Biophys Acta, 2001 Apr 16. PMID 11311949
    4. Fertility-related proteomic profiling bull spermatozoa separated by percoll. Park YJ, et al. J Proteome Res, 2012 Aug 3. PMID 22794312
    5. Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum. Hinsch KD, et al. J Biol Chem, 2004 Apr 9. PMID 14739283

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ENO1, VDAC2, and UQCRC2 were significantly correlated with individual fertility in bulls.
      Title: Fertility-related proteomic profiling bull spermatozoa separated by percoll.
    2. Multiple spots on 2D gel representing VDAC2 protein forms with different isoelectric points.
      Title: Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria.
    3. Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.
      Title: Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria.
    4. The present study is the first work to report the purification and characterization of VDAC2 from a mammalian tissue.
      Title: Molecular and functional characterization of VDAC2 purified from mammal spermatozoa.
    5. Confirm the localisation of VDAC2 in the acrosomal region of bovine spermatozoa using immunoelectron microscopy.
      Title: Localisation and function of voltage-dependent anion channels (VDAC) in bovine spermatozoa.
    6. VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria
      Title: Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent anion-selective channel protein 2
    Names
    VDAC-2
    outer mitochondrial membrane protein porin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174486.3 → NP_776911.2  voltage-dependent anion-selective channel protein 2

      See identical proteins and their annotated locations for NP_776911.2

      Status: PROVISIONAL

      Source sequence(s)
      BT021018
      UniProtKB/Swiss-Prot
      P68002, Q5E9A2, Q9MYV7, Q9TT14
      UniProtKB/TrEMBL
      A0AAA9TU27
      Related
      ENSBTAP00000086816.1, ENSBTAT00000098979.1
      Conserved Domains (1) summary
      cd07306
      Location:15 → 293
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      30970396..30984667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059882433.1 → XP_059738416.1  voltage-dependent anion-selective channel protein 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TU27
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68002.2 GenPept UniProtKB/Swiss-Prot:P68002

    Gene LinkOut

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