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    RDH5 retinol dehydrogenase 5 [ Bos taurus (domestic cattle) ]

    Gene ID: 281448, updated on 30-Jan-2025

    Summary

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    Official Symbol
    RDH5provided by VGNC
    Official Full Name
    retinol dehydrogenase 5provided by VGNC
    Primary source
    VGNC:VGNC:33843
    See related
    BGD:BT19116; EnsemblRapid:ENSBTAG00070014802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    P32; 9cRDH
    Orthologs
    human mouse all
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    Genomic context

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    See RDH5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (57533652..57538091, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101903534 Neighboring gene CD63 molecule Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 1 Neighboring gene integrin subunit alpha 7 Neighboring gene thiol methyltransferase 1B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of a cDNA encoding bovine retinal pigment epithelial 11-cis retinol dehydrogenase. Driessen CA, et al. Invest Ophthalmol Vis Sci, 1995 Sep. PMID 7544779
    2. The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases. Simon A, et al. J Biol Chem, 1995 Jan 20. PMID 7836368
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retinoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retinol dehydrogenase 5
    Names
    11-cis RDH
    11-cis RoDH
    11-cis retinol dehydrogenase
    9-cis retinol dehydrogenase
    retinol dehydrogenase 5 (11-cis and 9-cis)
    retinol dehydrogenase 5 (11-cis/9-cis)
    NP_776591.2
    XP_010803418.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174166.3 → NP_776591.2  retinol dehydrogenase 5

      See identical proteins and their annotated locations for NP_776591.2

      Status: VALIDATED

      Source sequence(s)
      EV670727, EV737918
      UniProtKB/Swiss-Prot
      F1ML51, Q27979, Q28004
      Related
      ENSBTAP00070019746.1, ENSBTAT00070033451.1
      Conserved Domains (2) summary
      pfam00106
      Location:31 → 213
      adh_short; short chain dehydrogenase
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      57533652..57538091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010805116.4 → XP_010803418.1  retinol dehydrogenase 5 isoform X1

      Conserved Domains (2) summary
      pfam00106
      Location:101 → 283
      adh_short; short chain dehydrogenase
      cl21454
      Location:100 → 376
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27979.1 GenPept UniProtKB/Swiss-Prot:Q27979

    Gene LinkOut

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