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    NEU3 neuraminidase 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 281349, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NEU3provided by VGNC
    Official Full Name
    neuraminidase 3provided by VGNC
    Primary source
    VGNC:VGNC:54889
    See related
    BGD:BT10628; Ensembl:ENSBTAG00000025931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NEU3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (54247469..54270762)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene signal peptidase complex subunit 2 Neighboring gene olfactory receptor family 2 subfamily AT member 2C Neighboring gene olfactory receptor family 2 subfamily AT member 2B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a plasma membrane-associated sialidase specific for gangliosides. Miyagi T, et al. J Biol Chem, 1999 Feb 19. PMID 9988745
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables exo-alpha-sialidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ganglioside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in oligosaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sialidase-3
    Names
    N-acetyl-alpha-neuraminidase 3
    ganglioside sialidase
    membrane sialidase
    sialidase 3 (membrane sialidase)
    NP_776547.2
    XP_010810989.1
    XP_024830753.1
    XP_024830754.1
    XP_059730535.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174122.3 → NP_776547.2  sialidase-3

      Status: VALIDATED

      Source sequence(s)
      AB008184
      UniProtKB/Swiss-Prot
      O97859
      Related
      ENSBTAP00070043850.1, ENSBTAT00070071822.1
      Conserved Domains (2) summary
      cd15482
      Location:21 → 414
      Sialidase_non-viral; Non-viral sialidases
      pfam13088
      Location:47 → 395
      BNR_2; BNR repeat-like domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      54247469..54270762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059874552.1 → XP_059730535.1  sialidase-3 isoform X1

      UniProtKB/Swiss-Prot
      O97859
      UniProtKB/TrEMBL
      A0AAA9TU08

    2. XM_024974985.2 → XP_024830753.1  sialidase-3 isoform X1

      UniProtKB/Swiss-Prot
      O97859
      UniProtKB/TrEMBL
      A0AAA9TU08
      Related
      ENSBTAP00070043815.1, ENSBTAT00070071771.1
      Conserved Domains (1) summary
      cd15482
      Location:55 → 448
      Sialidase_non-viral; Non-viral sialidases

    3. XM_024974986.2 → XP_024830754.1  sialidase-3 isoform X2

      UniProtKB/Swiss-Prot
      O97859
      Conserved Domains (1) summary
      cd15482
      Location:25 → 418
      Sialidase_non-viral; Non-viral sialidases

    4. XM_010812687.4 → XP_010810989.1  sialidase-3 isoform X2

      See identical proteins and their annotated locations for XP_010810989.1

      UniProtKB/Swiss-Prot
      O97859
      Related
      ENSBTAP00070043797.1, ENSBTAT00070071744.1
      Conserved Domains (1) summary
      cd15482
      Location:25 → 418
      Sialidase_non-viral; Non-viral sialidases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97859.1 GenPept UniProtKB/Swiss-Prot:O97859

    Gene LinkOut

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    Research Materials