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    FSCN2 fascin actin-bundling protein 2, retinal [ Bos taurus (domestic cattle) ]

    Gene ID: 337926, updated on 27-Dec-2024

    Summary

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    Official Symbol
    FSCN2provided by VGNC
    Official Full Name
    fascin actin-bundling protein 2, retinalprovided by VGNC
    Primary source
    VGNC:VGNC:29127
    See related
    BGD:BT29770; Ensembl:ENSBTAG00000024932
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FSCN2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (51235675..51247557, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene NPL4 homolog, ubiquitin recognition factor Neighboring gene FA core complex associated protein 100 Neighboring gene microRNA mir-3533 Neighboring gene actin gamma 1 Neighboring gene BAH domain and coiled-coil containing 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA encoding a photoreceptor cell-specific actin-bundling protein: retinal fascin. Saishin Y, et al. FEBS Lett, 1997 Sep 8. PMID 9315724
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fascin-2
    Names
    fascin 2, retinal
    fascin homolog 2, actin-bundling protein, retinal
    retinal fascin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176633.3 → NP_788806.1  fascin-2

      See identical proteins and their annotated locations for NP_788806.1

      Status: PROVISIONAL

      Source sequence(s)
      AB003485
      UniProtKB/Swiss-Prot
      O18728
      UniProtKB/TrEMBL
      A0AAF6ZCA1
      Related
      ENSBTAP00000034620.4, ENSBTAT00000034735.5
      Conserved Domains (2) summary
      cd00257
      Location:381 → 492
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:266 → 376
      Fascin; Fascin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51235675..51247557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979659.2 → XP_024835427.1  fascin-2 isoform X1

      UniProtKB/TrEMBL
      A0AAF6ZCA1
      Conserved Domains (2) summary
      cd00257
      Location:410 → 521
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:266 → 370
      Fascin; Fascin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18728.1 GenPept UniProtKB/Swiss-Prot:O18728

    Gene LinkOut

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    Research Materials