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    NDST2 N-deacetylase and N-sulfotransferase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 286838, updated on 29-Jan-2025

    Summary

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    Gene symbol
    NDST2
    Gene description
    N-deacetylase and N-sulfotransferase 2
    See related
    BGD:BT20546; Ensembl:ENSBTAG00000012664
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NDST2 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (29696608..29704955, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene plasminogen activator, urokinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cells. Toma L, et al. J Biol Chem, 1998 Aug 28. PMID 9712870
    2. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Ishiwata H, et al. Mol Reprod Dev, 2003 May. PMID 12658628
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC154982

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
    Names
    CCL44
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
    N-deacetylase/N-sulfotransferase 2
    NDST-2
    glucosaminyl N-deacetylase/N-sulfotransferase 2
    NP_777202.2
    XP_005226388.1
    XP_010818836.1
    XP_024842343.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174777.3 → NP_777202.2  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

      See identical proteins and their annotated locations for NP_777202.2

      Status: PROVISIONAL

      Source sequence(s)
      BC134688
      UniProtKB/Swiss-Prot
      O97583, Q862Q7, Q862Y7
      UniProtKB/TrEMBL
      A8E4L2
      Related
      ENSBTAP00070037448.1, ENSBTAT00070062593.1
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25 → 514
      HSNSD; heparan sulfate-N-deacetylase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29696608..29704955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226331.5 → XP_005226388.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_005226388.1

      UniProtKB/Swiss-Prot
      O97583, Q862Q7, Q862Y7
      UniProtKB/TrEMBL
      A8E4L2
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25 → 514
      HSNSD; heparan sulfate-N-deacetylase

    2. XM_024986575.2 → XP_024842343.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X3

      UniProtKB/Swiss-Prot
      O97583, Q862Q7, Q862Y7
      UniProtKB/TrEMBL
      A0A3Q1LTF8
      Related
      ENSBTAP00070037468.1, ENSBTAT00070062614.1
      Conserved Domains (2) summary
      pfam00685
      Location:541 → 790
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25 → 452
      HSNSD; heparan sulfate-N-deacetylase

    3. XM_010820534.4 → XP_010818836.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2

      UniProtKB/Swiss-Prot
      O97583, Q862Q7, Q862Y7
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 835
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25 → 514
      HSNSD; heparan sulfate-N-deacetylase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97583.1 GenPept UniProtKB/Swiss-Prot:O97583

    Gene LinkOut

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