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    RASA3 RAS p21 protein activator 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 282532, updated on 30-Jan-2025

    Summary

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    Official Symbol
    RASA3provided by VGNC
    Official Full Name
    RAS p21 protein activator 3provided by VGNC
    Primary source
    VGNC:VGNC:33737
    See related
    BGD:BT16149; EnsemblRapid:ENSBTAG00070010550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GAP1IP4BP; GAP1(IP4BP)
    Orthologs
    human mouse all
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    Genomic context

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    See RASA3 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (86908875..86988638, complement)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112449102 Neighboring gene growth arrest specific 6 Neighboring gene chromosome 12 C13orf46 homolog Neighboring gene uncharacterized LOC112449104 Neighboring gene uncharacterized LOC132346809 Neighboring gene large ribosomal subunit protein eL22-like Neighboring gene CFAP97 domain containing 2 Neighboring gene cell division cycle 16 Neighboring gene microRNA mir-2303

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A novel GTPase-activating protein for R-Ras. Yamamoto T, et al. J Biol Chem, 1995 Dec 22. PMID 8530488
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating protein 3
    Names
    RAS p21 protein activator (GTPase activating protein) 3 (Ins(1,3,4,5)P4-binding protein)
    ins P4-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174676.4 → NP_777101.2  ras GTPase-activating protein 3

      See identical proteins and their annotated locations for NP_777101.2

      Status: VALIDATED

      Source sequence(s)
      BC140572, NKLS02000012
      UniProtKB/Swiss-Prot
      Q28013
      UniProtKB/TrEMBL
      A5D7I7, F1N4G2
      Related
      ENSBTAP00070013965.1, ENSBTAT00070023604.1
      Conserved Domains (7) summary
      smart00107
      Location:679 → 714
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:146 → 288
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:13 → 133
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:297 → 565
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      smart00323
      Location:275 → 614
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13371
      Location:562 → 686
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      pfam00169
      Location:577 → 676
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      86908875..86988638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28013.1 GenPept UniProtKB/Swiss-Prot:Q28013

    Gene LinkOut

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