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    MARCHF8 membrane associated ring-CH-type finger 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 540667, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MARCHF8provided by VGNC
    Official Full Name
    membrane associated ring-CH-type finger 8provided by VGNC
    Primary source
    VGNC:VGNC:55990
    See related
    BGD:BT17500; EnsemblRapid:ENSBTAG00070017232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    c-MIR; MARCH8
    Orthologs
    human mouse all
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    Genomic context

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    See MARCHF8 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (44228074..44339177)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 2C Neighboring gene zinc finger AN1-type containing 4 Neighboring gene uncharacterized LOC112444772 Neighboring gene arachidonate 5-lipoxygenase Neighboring gene olfactory receptor family 13 subfamily A member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138116

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF8
    Names
    E3 ubiquitin-protein ligase MARCH8
    MARCH-VIII
    RING-type E3 ubiquitin transferase MARCH8
    RING-type E3 ubiquitin transferase MARCHF8
    cellular modulator of immune recognition
    membrane-associated RING finger protein 8
    membrane-associated RING-CH protein VIII
    membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
    NP_001069700.1
    XP_005226656.1
    XP_010819023.1
    XP_010819025.1
    XP_010819027.1
    XP_024842521.1
    XP_059738566.1
    XP_059738567.1
    XP_059738568.1
    XP_059738569.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076232.1 → NP_001069700.1  E3 ubiquitin-protein ligase MARCHF8

      See identical proteins and their annotated locations for NP_001069700.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119819
      UniProtKB/Swiss-Prot
      Q0VD59
      UniProtKB/TrEMBL
      A0AAF6ZDK0
      Related
      ENSBTAP00070023041.1, ENSBTAT00070038858.1
      Conserved Domains (1) summary
      cd16698
      Location:77 → 128
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44228074..44339177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059882585.1 → XP_059738568.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6

    2. XM_059882583.1 → XP_059738566.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6

    3. XM_059882584.1 → XP_059738567.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6

    4. XM_010820721.4 → XP_010819023.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      See identical proteins and their annotated locations for XP_010819023.1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6
      Conserved Domains (1) summary
      cd16698
      Location:358 → 409
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    5. XM_005226599.5 → XP_005226656.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      See identical proteins and their annotated locations for XP_005226656.1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6
      Related
      ENSBTAP00070023036.1, ENSBTAT00070038849.1
      Conserved Domains (1) summary
      cd16698
      Location:358 → 409
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    6. XM_010820725.4 → XP_010819027.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      See identical proteins and their annotated locations for XP_010819027.1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6
      Conserved Domains (1) summary
      cd16698
      Location:358 → 409
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    7. XM_010820723.4 → XP_010819025.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      See identical proteins and their annotated locations for XP_010819025.1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6
      Conserved Domains (1) summary
      cd16698
      Location:358 → 409
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    8. XM_024986753.2 → XP_024842521.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6
      Conserved Domains (1) summary
      cd16698
      Location:358 → 409
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    9. XM_059882586.1 → XP_059738569.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S6V3, A0AAA9SVJ6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VD59.1 GenPept UniProtKB/Swiss-Prot:Q0VD59

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