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    NADSYN1 NAD synthetase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 513400, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NADSYN1provided by VGNC
    Official Full Name
    NAD synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:31865
    See related
    BGD:BT25748; Ensembl:ENSBTAG00000016470
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NADSYN1 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (48309539..48337338)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344215 Neighboring gene 7-dehydrocholesterol reductase Neighboring gene mas-related G-protein coupled receptor member B5 Neighboring gene uncharacterized LOC132344214

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127343

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamine-dependent NAD(+) synthetase
    Names
    NAD(+) synthase
    NAD(+) synthetase 1
    NP_001029615.1
    XP_005227393.1
    XP_024842844.1
    XP_024842846.1
    XP_024842847.1
    XP_024842848.1
    XP_059738850.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034443.2 → NP_001029615.1  glutamine-dependent NAD(+) synthetase

      See identical proteins and their annotated locations for NP_001029615.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103388
      UniProtKB/Swiss-Prot
      Q3ZBF0
      UniProtKB/TrEMBL
      A0A452DIQ2
      Related
      ENSBTAP00000074390.2, ENSBTAT00000077400.2
      Conserved Domains (3) summary
      cd07570
      Location:6 → 287
      GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
      PLN02339
      Location:3 → 696
      PLN02339; NAD+ synthase (glutamine-hydrolysing)
      cd00553
      Location:327 → 650
      NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48309539..48337338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005227336.5 → XP_005227393.1  glutamine-dependent NAD(+) synthetase isoform X3

      UniProtKB/TrEMBL
      A0A452DIQ2
      Conserved Domains (3) summary
      cd07570
      Location:6 → 287
      GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
      PLN02339
      Location:3 → 704
      PLN02339; NAD+ synthase (glutamine-hydrolysing)
      cd00553
      Location:335 → 658
      NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

    2. XM_024987079.2 → XP_024842847.1  glutamine-dependent NAD(+) synthetase isoform X4

      UniProtKB/TrEMBL
      A0AAF7AU01
      Conserved Domains (1) summary
      cl28463
      Location:21 → 636
      PRK13981; NAD synthetase; Provisional

    3. XM_024987076.1 → XP_024842844.1  glutamine-dependent NAD(+) synthetase isoform X1

      Conserved Domains (1) summary
      cl28463
      Location:153 → 725
      PRK13981; NAD synthetase; Provisional

    4. XM_024987078.2 → XP_024842846.1  glutamine-dependent NAD(+) synthetase isoform X2

      Conserved Domains (1) summary
      cl28463
      Location:153 → 717
      PRK13981; NAD synthetase; Provisional

    5. XM_024987080.1 → XP_024842848.1  glutamine-dependent NAD(+) synthetase isoform X5

      Conserved Domains (1) summary
      cl28463
      Location:79 → 633
      PRK13981; NAD synthetase; Provisional

    6. XM_059882867.1 → XP_059738850.1  glutamine-dependent NAD(+) synthetase isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZBF0.1 GenPept UniProtKB/Swiss-Prot:Q3ZBF0

    Gene LinkOut

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