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    ICA1 islet cell autoantigen 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 535346, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ICA1provided by VGNC
    Official Full Name
    islet cell autoantigen 1provided by VGNC
    Primary source
    VGNC:VGNC:30023
    See related
    BGD:BT28483; Ensembl:ENSBTAG00000000799
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See ICA1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (16191714..16355628, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345170 Neighboring gene glucocorticoid induced 1 Neighboring gene elongation factor 1-beta-like Neighboring gene neurexophilin 1 Neighboring gene transfer RNA cysteine (anticodon GCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134001

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    islet cell autoantigen 1
    Names
    islet cell autoantigen 1, 69kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038168.1 → NP_001033257.1  islet cell autoantigen 1

      See identical proteins and their annotated locations for NP_001033257.1

      Status: PROVISIONAL

      Source sequence(s)
      BC109930
      UniProtKB/TrEMBL
      A0A3Q1MG19, Q32KU0
      Related
      ENSBTAP00000069488.2, ENSBTAT00000081695.2
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      16191714..16355628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205193.5 → XP_005205250.1  islet cell autoantigen 1 isoform X2

      See identical proteins and their annotated locations for XP_005205250.1

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 508
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    2. XM_024990774.2 → XP_024846542.1  islet cell autoantigen 1 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 448
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    3. XM_024990769.2 → XP_024846537.1  islet cell autoantigen 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    4. XM_005205188.5 → XP_005205245.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_005205245.1

      UniProtKB/TrEMBL
      A0A3Q1MG19, A0AAA9TV31
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 509
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    5. XM_024990772.2 → XP_024846540.1  islet cell autoantigen 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1MG19, F1MW75
      Related
      ENSBTAP00000001057.5, ENSBTAT00000001057.6
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 459
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    6. XM_005205186.5 → XP_005205243.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_005205243.1

      UniProtKB/TrEMBL
      A0A3Q1MG19, A0AAA9TV31
      Related
      ENSBTAP00000101247.1, ENSBTAT00000126758.1
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 509
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    7. XM_024990770.2 → XP_024846538.1  islet cell autoantigen 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 479
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    8. XM_005205192.5 → XP_005205249.1  islet cell autoantigen 1 isoform X2

      See identical proteins and their annotated locations for XP_005205249.1

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 508
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    9. XM_024990773.2 → XP_024846541.1  islet cell autoantigen 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1MG19, F1MW75
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 459
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    10. XM_024990768.2 → XP_024846536.1  islet cell autoantigen 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    11. XM_005205189.5 → XP_005205246.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_005205246.1

      UniProtKB/TrEMBL
      A0A3Q1MG19, A0AAA9TV31
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 509
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    12. XM_005205191.5 → XP_005205248.1  islet cell autoantigen 1 isoform X2

      See identical proteins and their annotated locations for XP_005205248.1

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 508
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    13. XM_010804038.4 → XP_010802340.1  islet cell autoantigen 1 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 448
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    14. XM_010804036.4 → XP_010802338.1  islet cell autoantigen 1 isoform X6

      See identical proteins and their annotated locations for XP_010802338.1

      UniProtKB/TrEMBL
      A0A3Q1M1Y0, A0A3Q1MG19
      Related
      ENSBTAP00000067377.2, ENSBTAT00000074256.2
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 477
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    15. XM_010804037.4 → XP_010802339.1  islet cell autoantigen 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1MG19, F1MW75
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 459
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    16. XM_010804034.4 → XP_010802336.1  islet cell autoantigen 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 488
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    17. XM_010804035.4 → XP_010802337.1  islet cell autoantigen 1 isoform X4

      See identical proteins and their annotated locations for XP_010802337.1

      UniProtKB/TrEMBL
      A0A3Q1MG19
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    18. XM_005205187.5 → XP_005205244.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_005205244.1

      UniProtKB/TrEMBL
      A0A3Q1MG19, A0AAA9TV31
      Conserved Domains (2) summary
      cd07661
      Location:53 → 256
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 509
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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