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    EGR4 early growth response 4 [ Homo sapiens (human) ]

    Gene ID: 1961, updated on 3-Dec-2024

    Summary

    Official Symbol
    EGR4provided by HGNC
    Official Full Name
    early growth response 4provided by HGNC
    Primary source
    HGNC:HGNC:3241
    See related
    Ensembl:ENSG00000135625 MIM:128992; AllianceGenome:HGNC:3241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AT133; NGFIC; NGFI-C; PAT133
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 3.5) and testis (RPKM 1.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EGR4 in Genome Data Viewer
    Location:
    2p13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73290929..73293548, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73300923..73306546, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73518057..73520676, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene F-box protein 41 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:73496386-73497329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11641 Neighboring gene uncharacterized LOC124907840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:73518267-73518962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11644 Neighboring gene RNA, U6 small nuclear 111, pseudogene Neighboring gene uncharacterized LOC105374802

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of early growth response 4 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    early growth response protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001965.4NP_001956.4  early growth response protein 4

      Status: VALIDATED

      Source sequence(s)
      AC010913
      Consensus CDS
      CCDS1925.3
      UniProtKB/Swiss-Prot
      B2RAE3, G3V1T5, Q05215, Q2Z1P5
      UniProtKB/TrEMBL
      A0A0C4DG96
      Related
      ENSP00000419687.1, ENST00000436467.4
      Conserved Domains (3) summary
      COG5048
      Location:408466
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26464
      Location:74339
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      73290929..73293548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443603.1XP_047299559.1  early growth response protein 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAE3, G3V1T5, Q05215, Q2Z1P5
      UniProtKB/TrEMBL
      B7ZKU3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      73300923..73306546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340923.1XP_054196898.1  early growth response protein 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAE3, G3V1T5, Q05215, Q2Z1P5
      UniProtKB/TrEMBL
      B7ZKU3