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    Cpr Cytochrome P450 reductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cprprovided by FlyBase
    Official Full Name
    Cytochrome P450 reductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015623
    Locus tag
    Dmel_CG11567
    See related
    AllianceGenome:FB:FBgn0015623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CCR; CG11567; cpr; CPR; DmCPR; Dmel\CG11567; DMR; NCPR; P450
    Summary
    Predicted to enable FMN binding activity; NADPH-hemoprotein reductase activity; and flavin adenine dinucleotide binding activity. Involved in cuticle hydrocarbon biosynthetic process. Located in endomembrane system. Is expressed in several structures, including adult heart; embryonic/larval midgut primordium; epithelium; gut section; and organism subdivision. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome with disordered steroidogenesis; congenital adrenal hyperplasia; and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpr in Genome Data Viewer
    Location:
    26C3-26C3; 2-19 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6338836..6346280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6338836..6346280)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing guanine nucleotide exchange factor Neighboring gene Pez Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene amplification and microsatellite polymorphism underlie a recent insect host shift. Bass C, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218582, Free PMC Article
    2. Drosophila melanogaster NADPH-cytochrome P450 oxidoreductase: pronounced expression in antennae may be related to odorant clearance. Hovemann BT, et al. Gene, 1997 Apr 21. PMID 9168130
    3. Differential metabolism of neonicotinoids by brown planthopper, Nilaparvata lugens, CYP6ER1 variants. Hamada A, et al. Pestic Biochem Physiol, 2020 May. PMID 32359560
    4. An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis. Qiu Y, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927409, Free PMC Article
    5. Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation. Helvig C, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555597

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH-hemoprotein reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH-hemoprotein reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH-hemoprotein reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cuticle hydrocarbon biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitric oxide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 reductase
    Names
    CG11567-PA
    CG11567-PB
    CG11567-PC
    CG11567-PD
    Cpr-PA
    Cpr-PB
    Cpr-PC
    Cpr-PD
    NADPH--ferrihemoprotein reductase; NADPH-cytochrome P450 reductase
    NADPH-cytochrome P450 oxidoreductase
    NADPH-cytochrome P450 reductase
    P450 reductase
    cytochrome c reductase (NADPH)
    NP_001260128.1
    NP_001260129.1
    NP_477158.1
    NP_723173.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6338836..6346280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057810.4 → NP_477158.1  cytochrome P450 reductase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477158.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27597, Q9VMF2
      UniProtKB/TrEMBL
      A0A6C0PTF0, M9PCQ1
      Related
      FBpp0078880
      Conserved Domains (3) summary
      cd06204
      Location:281 → 678
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:80 → 678
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:86 → 223
      Flavodoxin_1; Flavodoxin

    2. NM_001273200.1 → NP_001260129.1  cytochrome P450 reductase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27597, Q9VMF2
      UniProtKB/TrEMBL
      A0A6C0PTF0, M9PCQ1
      Conserved Domains (3) summary
      cd06204
      Location:281 → 678
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:80 → 678
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:86 → 223
      Flavodoxin_1; Flavodoxin

    3. NM_001273199.1 → NP_001260128.1  cytochrome P450 reductase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27597, Q9VMF2
      UniProtKB/TrEMBL
      A0A6C0PTF0, M9PCQ1
      Conserved Domains (3) summary
      cd06204
      Location:281 → 678
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:80 → 678
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:86 → 223
      Flavodoxin_1; Flavodoxin

    4. NM_164689.2 → NP_723173.1  cytochrome P450 reductase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMD4, Q8IPJ7
      Related
      FBpp0078881
      Conserved Domains (3) summary
      cd06204
      Location:152 → 549
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:45 → 549
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:45 → 94
      Flavodoxin_1; Flavodoxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCQ1 M9PCQ1
    Q27597.2 Q27597
    Q8IPJ7 Q8IPJ7

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