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    Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hrb27Cprovided by FlyBase
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein at 27Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004838
    Locus tag
    Dmel_CG10377
    See related
    AllianceGenome:FB:FBgn0004838
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10280; CG10377; Dmel\CG10377; hnRNP-C; hnRNP27C; hnRNP48; hrb27; Hrb27-C; hrb27c; hrb27C; Hrb27c; HRB27C; Hrb27C/Hrp48; Hrb48; hrp48; Hrp48; HRP48; Hrp48/Hrb27C; l(2)02647; l(2)10280; l(2)2647; linha; Ov5; p50; Rbp7; rrm7; RRM7
    Summary
    Enables mRNA 3'-UTR binding activity; single-stranded DNA binding activity; and translation repressor activity. Involved in pole plasm oskar mRNA localization; positive regulation of border follicle cell migration; and regulation of gene expression. Located in P granule and nucleoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including adult central complex; adult head; brain; gonad; and imaginal disc. Orthologous to human DAZAP1 (DAZ associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hrb27C in Genome Data Viewer
    Location:
    27C4-27C4; 2-23 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6920704..6932057)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6920704..6932057)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene x16 splicing factor Neighboring gene nop5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fibroblast growth factor receptor 1 oncogene partner 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Hrp48 Is Required for Mushroom Body Axon Growth, Branching and Guidance. Bruckert H, et al. PLoS One, 2015. PMID 26313745, Free PMC Article
    2. Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. Siebel CW, et al. Genes Dev, 1994 Jul 15. PMID 7958851
    3. Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and Drosophila cells. Abruzzi KC, et al. RNA, 2023 Aug. PMID 37169395, Free PMC Article
    4. Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Siebel CW, et al. Genes Dev, 1995 Feb 1. PMID 7867926
    5. The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding. Siebel CW, et al. Genes Dev, 1992 Aug. PMID 1322855

    See all (192) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel roles for RNA binding proteins squid, hephaesteus, and Hrb27C in Drosophila oogenesis.
      Title: Novel roles for RNA binding proteins squid, hephaesteus, and Hrb27C in Drosophila oogenesis.
    2. The role of the heterogeneous nuclear ribonucleoprotein (hnRNP) Hrb27C in regulating lipid storage in the Drosophila fat body.
      Title: The role of the heterogeneous nuclear ribonucleoprotein (hnRNP) Hrb27C in regulating lipid storage in the Drosophila fat body.
    3. REVIEW: Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex in the Regulation of Notch Signaling
      Title: Regulation of Notch Signaling in Drosophila melanogaster: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex.
    4. The data is consistent with a model where Hrp48 inhibits msl-2 translation by targeting eIF3d.
      Title: Hrp48 and eIF3d contribute to msl-2 mRNA translational repression.
    5. coexpression of Dx and Hrp48 activates JNK pathway to induce cell death in eye disc of Drosophila melanogaster.
      Title: Synergistic interaction of Deltex and Hrp48 leads to JNK activation.
    6. we observed that Dx together with Hrp48 can regulate Notch signaling in an Sxl-independent manner. In addition, Dx and Hrp48 displayed a synergistic effect on caspase-mediated cell death. Our results suggest that Dx and Hrp48 together negatively regulate Notch signaling in Drosophila melanogaster.
      Title: Regulation of Notch Signaling by the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster.
    7. data provide evidence for a crucial in vivo role of the hnRNP Hrp48 in multiple aspects of axon guidance and branching during nervous system development.
      Title: Drosophila Hrp48 Is Required for Mushroom Body Axon Growth, Branching and Guidance.
    8. Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development
      Title: Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development.
    9. Three proteins (DDP1, Hrp48, and poly(A)-binding protein) are components of the HDE-binding complex and function in translational enhancement
      Title: A multiprotein complex that mediates translational enhancement in Drosophila.
    10. Data show that Squid (Sqd) interacts with Hrb27C, and that Ovarian tumor (Otu) cooperates with Hrb27C and Sqd in the oocyte to mediate proper gurken (grk) localization.
      Title: Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(G) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of oskar mRNA translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein at 27C
    Names
    CG10377-PA
    CG10377-PB
    CG10377-PC
    CG10377-PD
    CG10377-PE
    CG10377-PF
    CG10377-PG
    CG10377-PH
    Hrb27C-PA
    Hrb27C-PB
    Hrb27C-PC
    Hrb27C-PD
    Hrb27C-PE
    Hrb27C-PF
    Hrb27C-PG
    Hrb27C-PH
    RNA-binding protein 7
    heterogeneous nuclear ribonucleoprotein
    linha

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6920704..6932057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258990.2 → NP_001245919.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245919.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    2. NM_057521.6 → NP_476869.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476869.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Related
      FBpp0078974
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    3. NM_001169426.2 → NP_001162897.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    4. NM_001258989.2 → NP_001245918.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    5. NM_001258988.2 → NP_001245917.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    6. NM_164721.3 → NP_723229.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723229.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Related
      FBpp0078975
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    7. NM_164720.4 → NP_723228.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Related
      FBpp0078976
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    8. NM_001169427.2 → NP_001162898.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0B8, P48809, Q7JPT5, Q9TY67, Q9VM68
      UniProtKB/TrEMBL
      E1JHA4, L0CRY8
      Conserved Domains (2) summary
      cd12327
      Location:94 → 173
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:8 → 89
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHA4 E1JHA4
    P48809.2 P48809

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