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    Jon99Fi Jonah 99Fi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon99Fiprovided by FlyBase
    Official Full Name
    Jonah 99Fiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039778
    Locus tag
    Dmel_CG18030
    See related
    AllianceGenome:FB:FBgn0039778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18030; Dmel\CG18030; Jon99F; SP181; SPH181
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Jon99Fi in Genome Data Viewer
    Location:
    99F6-99F6; 3-100 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30488963..30489895)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26314685..26315617)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene prolyl-4-hydroxylase-alpha EFB Neighboring gene sanpodo Neighboring gene Jonah 99Fii Neighboring gene prolyl-4-hydroxylase-alpha SG2 Neighboring gene prolyl-4-hydroxylase-alpha MP Neighboring gene prolyl-4-hydroxylase-alpha NE1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
    2. The Jonah genes: a new multigene family in Drosophila melanogaster. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416610
    3. Quantitative evolutionary genomics: differential gene expression and male reproductive success in Drosophila melanogaster. Drnevich JM, et al. Proc Biol Sci, 2004 Nov 7. PMID 15539352, Free PMC Article
    4. Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Abrams EW, et al. Development, 2006 Sep. PMID 16914497
    5. Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. Parisi MJ, et al. BMC Genomics, 2010 Jun 1. PMID 20515475, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 99Fi
    Names
    CG18030-PA
    Jon99Fi-PA
    jonah 99F
    NP_651800.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30488963..30489895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143543.3 → NP_651800.2  jonah 99Fi [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651800.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYK8, Q9VA66
      Related
      FBpp0085014
      Conserved Domains (2) summary
      smart00020
      Location:37 → 259
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:38 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYK8 Q8SYK8
    Q9VA66 Q9VA66

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