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    Srp72 Signal recognition particle 72 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srp72provided by FlyBase
    Official Full Name
    Signal recognition particle 72provided by FlyBase
    Primary source
    FLYBASE:FBgn0038810
    Locus tag
    Dmel_CG5434
    See related
    AllianceGenome:FB:FBgn0038810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5434; Dmel\CG5434; SRP72
    Summary
    Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Involved in dsRNA transport. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in adult head and adult heart. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Srp72 in Genome Data Viewer
    Location:
    92F2-92F2; 3-69 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20588711..20591040)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16414433..16416762)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46044 Neighboring gene Septin 2 Neighboring gene Pseudouridine synthase 1 Neighboring gene bonus Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
    2. Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling. Schroeder AM, et al. PLoS Genet, 2022 Oct. PMID 36240221, Free PMC Article
    3. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article
    4. CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Abrams EW, et al. Development, 2005 Jun. PMID 15901661
    5. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of signal recognition particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle 72
    Names
    CG5434-PA
    Srp72-PA
    signal recognition particle protein 72

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20588711..20591040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142641.3 → NP_650898.1  signal recognition particle 72 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BHY9, Q9VDK7
      Related
      FBpp0083319
      Conserved Domains (4) summary
      sd00006
      Location:45 → 71
      TPR; TPR repeat [structural motif]
      pfam08492
      Location:534 → 583
      SRP72; SRP72 RNA-binding domain
      pfam12895
      Location:24 → 101
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam17004
      Location:52 → 155
      SRP_TPR_like; Putative TPR-like repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BHY9 Q5BHY9
    Q95SX0 Q95SX0
    Q9VDK7 Q9VDK7

    Gene LinkOut

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