Fcp1 TFIIF-interacting CTD phosphatase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fcp1provided by FlyBase
Official Full Name: TFIIF-interacting CTD phosphataseprovided by FlyBase
Primary source: FLYBASE:FBgn0035026
Locus tag: Dmel_CG12252
See related: AllianceGenome:FB:FBgn0035026
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 21483550; CG12252; Dmel\CG12252; Dmfcp1; DmFcp1; fcp1
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Located in nucleus and polytene chromosome. Is expressed in nurse cell. Orthologous to human CTDP1 (CTD phosphatase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60D5-60D5; 2-107 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24567987..24571821, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20455510..20459344, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

used transgene constructs to modify the Fcp1 phosphatase level in ovaries and found that high levels of Fcp1 are required for intensive gene expression in nurse cells
Title: High Fcp1 phosphatase activity contributes to setting an intense transcription rate required in Drosophila nurse and follicular cells for egg production.
Fcp1 binds to specific regions of the polytene chromosomes at many sites colocalized with Pol II.
Title: The RNA Pol II CTD phosphatase Fcp1 is essential for normal development in Drosophila melanogaster.
Results show that in Drosophila, misregulated expression of the RNA polymerase II carboxyl-terminal domain-specific phosphatase Fcp1 induces p53-dependent but transcription-independent apoptosis.
Title: Misregulated RNA Pol II C-terminal domain phosphorylation results in apoptosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TFIIF-interacting CTD phosphatase

Names: CG12252-PA; CG12252-PB; Fcp1-PA; Fcp1-PB; RNApolymerase II carboxyl-terminal domain phosphatase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24567987..24571821 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299917.1 → NP_001286846.1 TFIIF-interacting CTD phosphatase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286846.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQY2, Q9W147

Conserved Domains (4) summary

TIGR02250
Location:202 → 348

FCP1_euk; FCP1-like phosphatase, phosphatase domain

COG5275
Location:481 → 658

COG5275; BRCT domain type II [General function prediction only]

pfam00533
Location:587 → 665

BRCT; BRCA1 C Terminus (BRCT) domain

cl11404
Location:59 → 142

Biotinyl_lipoyl_domains; Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...
NM_138090.2 → NP_611934.1 TFIIF-interacting CTD phosphatase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611934.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQY2, Q9W147

Related

FBpp0072249

Conserved Domains (4) summary

TIGR02250
Location:202 → 348

FCP1_euk; FCP1-like phosphatase, phosphatase domain

COG5275
Location:481 → 658

COG5275; BRCT domain type II [General function prediction only]

pfam00533
Location:587 → 665

BRCT; BRCA1 C Terminus (BRCT) domain

cl11404
Location:59 → 142

Biotinyl_lipoyl_domains; Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...