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    Paip1 Poly(A) binding protein interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paip1provided by FlyBase
    Official Full Name
    Poly(A) binding protein interacting protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034181
    Locus tag
    Dmel_CG8963
    See related
    AllianceGenome:FB:FBgn0034181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8963; Dmel\CG8963
    Summary
    Predicted to enable translation activator activity. Involved in positive regulation of translation. Is expressed in adult head and organism. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Paip1 in Genome Data Viewer
    Location:
    53E4-53E4; 2-81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17016226..17019522, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12903731..12907027, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Eps15 homology domain containing protein-binding protein 1 Neighboring gene antisense RNA:CR44390 Neighboring gene Death-associated APAF1-related killer Neighboring gene Rho guanine nucleotide exchange factor 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Akdemir F, et al. Development, 2006 Apr. PMID 16540507
    2. A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. Funakoshi M, et al. Biochem Biophys Res Commun, 2011 Feb 25. PMID 21281604
    3. Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1. Xue M, et al. Cell Death Discov, 2023 Aug 5. PMID 37543696, Free PMC Article
    4. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article
    5. Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Yamamoto A, et al. Proc Natl Acad Sci U S A, 2008 Aug 26. PMID 18713854, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Poly(A) binding protein interacting protein 1
    Names
    CG8963-PA
    CG8963-PB
    CG8963-PC
    CG8963-PE
    Paip1-PA
    Paip1-PB
    Paip1-PC
    Paip1-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17016226..17019522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206145.3 → NP_995867.1  Poly(A) binding protein interacting protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K581
      Conserved Domains (1) summary
      smart00543
      Location:270 → 472
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)

    2. NM_137336.4 → NP_611180.1  Poly(A) binding protein interacting protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K581
      Related
      FBpp0086167
      Conserved Domains (1) summary
      smart00543
      Location:270 → 472
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)

    3. NM_001169700.2 → NP_001163171.1  Poly(A) binding protein interacting protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K581
      Conserved Domains (1) summary
      smart00543
      Location:270 → 472
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)

    4. NM_001259451.2 → NP_001246380.2  Poly(A) binding protein interacting protein 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246380.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K891
      Conserved Domains (1) summary
      smart00543
      Location:231 → 433
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K891 A0A0B4K891
    Q7K581 Q7K581

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