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    eIF4G2 eukaryotic translation initiation factor 4G2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF4G2provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4G2provided by FlyBase
    Primary source
    FLYBASE:FBgn0260634
    Locus tag
    Dmel_CG10192
    See related
    AllianceGenome:FB:FBgn0260634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10192; Dmel\CG10192; eIF4G; eIF4G-2; ms(3)nc32; nc32; ofs
    Summary
    Enables RNA 7-methylguanosine cap binding activity. Involved in male meiotic nuclear division and spermatogenesis. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in adult head; cyst cell of testis; male germline cell; and spermatocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF4G2 in Genome Data Viewer
    Location:
    95B9-95C1; 3-81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23808285..23819237, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19634007..19644959, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nucleoporin 98-96kD Neighboring gene myoblast city Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43285 Neighboring gene small nuclear RNA U1 at 95C c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis. Ghosh S, et al. PLoS One, 2015. PMID 25849588, Free PMC Article
    2. Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog. Baker CC, et al. Development, 2007 Aug. PMID 17611220, Free PMC Article
    3. Eukaryotic translation initiation factor eIF4E-5 is required for spermiogenesis in Drosophila melanogaster. Shao L, et al. Development, 2023 Feb 15. PMID 36695474
    4. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Hernández G, et al. Development, 2012 Sep. PMID 22833128, Free PMC Article
    5. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog, eIF4G2.
      Title: Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4G2
    Names
    CG10192-PA
    CG10192-PC
    eIF-4G-like protein
    eIF4G2-PA
    eIF4G2-PC
    male sterile (3) nc32
    off-schedule

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23808285..23819237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300560.1 → NP_001287489.1  eukaryotic translation initiation factor 4G2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCH1
      Conserved Domains (3) summary
      pfam02847
      Location:1697 → 1812
      MA3; MA3 domain
      pfam02854
      Location:1274 → 1514
      MIF4G; MIF4G domain
      cl04813
      Location:270 → 423
      EIN3; Ethylene insensitive 3

    2. NM_142931.4 → NP_651188.1  eukaryotic translation initiation factor 4G2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCH1
      Related
      FBpp0088566
      Conserved Domains (3) summary
      pfam02847
      Location:1697 → 1812
      MA3; MA3 domain
      pfam02854
      Location:1274 → 1514
      MIF4G; MIF4G domain
      cl04813
      Location:270 → 423
      EIN3; Ethylene insensitive 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4F9 Q8T4F9
    Q9VCH1 Q9VCH1

    Gene LinkOut

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