srp serpent [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: srpprovided by FlyBase
Official Full Name: serpentprovided by FlyBase
Primary source: FLYBASE:FBgn0003507
Locus tag: Dmel_CG3992
See related: AllianceGenome:FB:FBgn0003507
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A7.1; abf; Abf; ABF; CG3992; dGATAb; Dmel\CG3992; DmGATAb; GATA; GATAb; l(3)01549; l(3)89B2; l(3)neo45; spt; Srp; SRP; srpD
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; germ cell migration; and hemopoiesis. Part of RNA polymerase II transcription regulator complex. Is active in nucleus. Is expressed in several structures, including circulatory system primordium; endoderm anlage; hemocyte; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); bone marrow cancer (multiple); colon adenocarcinoma; depressive disorder; and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89A11-89A12; 3-58 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15986152..16004085)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11811874..11829803)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

bfc, a novel serpent co-factor for the expression of croquemort, regulates efferocytosis in Drosophila melanogaster.
Title: bfc, a novel serpent co-factor for the expression of croquemort, regulates efferocytosis in Drosophila melanogaster.
We uncovered an unanticipated interplay between dLsd1 and the GATA transcription factor Serpent and we report an unexpected role for Serpent in oogenesis.
Title: A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.
we demonstrate that the key regulator of Drosophila embryonic hemocyte differentiation, the transcription factor Serpent (Srp), plays a central role in establishing macrophage phagocytic competence during Drosophila embryogenesis
Title: Drosophila GATA Factor Serpent Establishes Phagocytic Ability of Embryonic Macrophages.
While either Snail or Serpent induced a profound loss of epithelial polarity and tissue organisation, Serpent but not Snail also induced an increase in the size of wing discs. Furthermore, the Serpent-induced tumour-like tissues were able to grow extensively when transplanted into the abdomen of adult hosts.
Title: Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth.
several genes work in a combined fashion to restrain early srp expression to the head mesoderm in order to prevent expansion of the hemocyte primordium
Title: Multiple regulatory safeguards confine the expression of the GATA factor Serpent to the hemocyte primordium within the Drosophila mesoderm.
A second 20E-mediated mechanism, which robustly affects only a subset of AMP genes, is uniquely controlled by BR-C, SRP and PNR.
Title: Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity.
Serpent regulates eater expression by binding to GATA sites.
Title: Transcriptional regulation of eater gene expression in Drosophila blood cells.
Mechanistic insights into hh transcriptional regulation in hematopoietic progenitor niche cells, demonstrate the requirement of the Srp, Su(H) and Ush proteins in the control of niche cell differentiation and blood cell precursor maintenance.
Title: Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis.
Data demonstrate that Med12 and Med13 but not CycC or Cdk8 are essential for Serpent/Lozenge-induced transactivation in cell culture.
Title: A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
Results show that the GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development.
Title: The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amnioserosa maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in crystal cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoderm development	TAS Traceable Author Statement more info	PubMed
involved_in endoderm formation	TAS Traceable Author Statement more info	PubMed
involved_in fat body development	IEP Inferred from Expression Pattern more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of crystal cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serpent

Names: A-box-binding factor; CG3992-PA; CG3992-PB; CG3992-PD; CG3992-PE; CG3992-PF; CG3992-PG; CG3992-PH; serpentD; srp-PA; srp-PB; srp-PD; srp-PE; srp-PF; srp-PG; srp-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15986152..16004085

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260199.2 → NP_001247128.1 serpent, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247128.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6J1

Conserved Domains (2) summary

smart00401
Location:265 → 314

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:269 → 320

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001032019.3 → NP_001027190.1 serpent, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027190.1

Status: REVIEWED

UniProtKB/TrEMBL

E2QCY6

Conserved Domains (2) summary

smart00401
Location:280 → 329

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:284 → 335

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001275690.1 → NP_001262619.1 serpent, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262619.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHL1

Conserved Domains (2) summary

smart00401
Location:280 → 329

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:284 → 335

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001275689.1 → NP_001262618.1 serpent, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262618.1

Status: REVIEWED

UniProtKB/TrEMBL

E2QCY6

Conserved Domains (2) summary

smart00401
Location:280 → 329

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:284 → 335

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_169694.3 → NP_732098.1 serpent, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732098.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P52172

Related

FBpp0082670

Conserved Domains (2) summary

smart00401
Location:783 → 832

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:787 → 838

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_169696.3 → NP_732100.2 serpent, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732100.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P52172, Q6NMW1, Q7K0H5, Q8INC6, Q94884, Q9VF01

Related

FBpp0082669

Conserved Domains (2) summary

smart00401
Location:798 → 847

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:802 → 853

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001382083.1 → NP_001369017.1 serpent, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EES8

Conserved Domains (1) summary

cd00202
Location:319 → 370

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C