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    Sbf SET domain binding factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41427, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sbfprovided by FlyBase
    Official Full Name
    SET domain binding factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025802
    Locus tag
    Dmel_CG6939
    See related
    AllianceGenome:FB:FBgn0025802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6939; Dmel\CG6939; dSbf1; DSbf1; MTMR5/13; sbf; SBF; Sbf1; SBF1
    Summary
    Enables several functions, including chromatin binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including endocytic recycling; positive regulation of metabolic process; and regulation of Rab protein signal transduction. Located in several cellular components, including cell cortex; polytene chromosome; and recycling endosome. Part of histone acetyltransferase complex; histone methyltransferase complex; and transcription elongation factor complex. Is expressed in adult head. Used to study epilepsy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B2 and Charcot-Marie-Tooth disease type 4B3. Orthologous to human SBF1 (SET binding factor 1) and SBF2 (SET binding factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sbf in Genome Data Viewer
    Location:
    86F8-86F8; 3-51 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11789293..11796948, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7615015..7622670, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45595 Neighboring gene pruning defect 1 Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene Chloride channel-a Neighboring gene glorund Neighboring gene Cytochrome c oxidase subunit 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and biochemical properties of the Drosophila TAC1 complex. Petruk S, et al. Methods Enzymol, 2004. PMID 14979030
    2. Efficient strategies based on behavioral and electrophysiological methods for epilepsy-related gene screening in the Drosophila model. Liu CQ, et al. Front Mol Neurosci, 2023. PMID 37152436, Free PMC Article
    3. uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways. Levivier E, et al. Biochem Biophys Res Commun, 2001 Sep 28. PMID 11563850
    4. A PtdIns(3,4,5)P(3) dispersal switch engages cell ratcheting at specific cell surfaces. Miao H, et al. Dev Cell, 2021 Sep 27. PMID 34525342, Free PMC Article
    5. Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Petruk S, et al. Science, 2001 Nov 9. PMID 11701926

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT enables phosphatase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein tyrosine phosphatase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription elongation factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SET domain binding factor
    Names
    CG6939-PA
    CG6939-PB
    Sbf-PA
    Sbf-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11789293..11796948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169430.3 → NP_731633.2  SET domain binding factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731633.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSP6, Q960A9
      Related
      FBpp0082004
      Conserved Domains (9) summary
      smart00801
      Location:384 → 452
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:1 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd00029
      Location:1771 → 1818
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01235
      Location:1868 → 1973
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13208
      Location:913 → 1027
      PH-GRAM_MTMR5_MTMR13; Myotubularian (MTM) related 5 and 13 proteins (MTMR5 and MTMR13) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:1871 → 1972
      PH; PH domain
      pfam02141
      Location:142 → 325
      DENN; DENN (AEX-3) domain
      pfam06602
      Location:1141 → 1545
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:565 → 787
      SBF2; Myotubularin protein

    2. NM_058053.4 → NP_477401.2  SET domain binding factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477401.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960A9, Q9VGH9
      Related
      FBpp0082003
      Conserved Domains (9) summary
      smart00801
      Location:384 → 452
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:1 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd00029
      Location:1791 → 1838
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01235
      Location:1888 → 1993
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13208
      Location:933 → 1047
      PH-GRAM_MTMR5_MTMR13; Myotubularian (MTM) related 5 and 13 proteins (MTMR5 and MTMR13) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:1891 → 1992
      PH; PH domain
      pfam02141
      Location:142 → 325
      DENN; DENN (AEX-3) domain
      pfam06602
      Location:1161 → 1565
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:585 → 807
      SBF2; Myotubularin protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96610 O96610
    Q7KSP6 Q7KSP6
    Q960A9 Q960A9
    Q9VGH9 Q9VGH9

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