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    hebe hebe [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hebeprovided by FlyBase
    Official Full Name
    hebeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033448
    Locus tag
    Dmel_CG1623
    See related
    AllianceGenome:FB:FBgn0033448
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1623; Dmel\CG1623
    Summary
    Involved in determination of adult lifespan. Is expressed in several structures, including adult head; embryonic antennal sense organ; embryonic/larval posterior spiracle; larval ventral midline glial cell; and ventral midline of embryo. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hebe in Genome Data Viewer
    Location:
    46B4-46B4; 2-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9828104..9836642, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5715609..5724147, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dilatory Neighboring gene uncharacterized protein Neighboring gene Lsm11 Neighboring gene Mitochondrial amidoxime reducing component Neighboring gene Vesicle-associated membrane protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion. Bing X, et al. Elife, 2024 Aug 7. PMID 39110499, Free PMC Article
    2. Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity. Li Y, et al. Mol Genet Genomics, 2009 Feb. PMID 19011900, Free PMC Article
    3. Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans. Fujioka M, et al. PLoS Genet, 2016 Feb. PMID 26910731, Free PMC Article
    4. Aging in the Drosophila ovary: contrasting changes in the expression of the piRNA machinery and mitochondria but no global release of transposable elements. Erwin AA, et al. BMC Genomics, 2019 Apr 23. PMID 31014230, Free PMC Article
    5. The song of the old mother: reproductive senescence in female drosophila. Miller PB, et al. Fly (Austin), 2014. PMID 25523082, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hebe
    Names
    CG1623-PB
    CG1623-PD
    CG1623-PE
    CG1623-PF
    hebe-PB
    hebe-PD
    hebe-PE
    hebe-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9828104..9836642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165700.3 → NP_724829.1  hebe, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K568
      Related
      FBpp0087571
      Conserved Domains (1) summary
      PRK10811
      Location:192 → 354
      rne; ribonuclease E; Reviewed

    2. NM_001103778.2 → NP_001097248.1  hebe, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097248.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K568
      Conserved Domains (1) summary
      PRK10811
      Location:192 → 354
      rne; ribonuclease E; Reviewed

    3. NM_165699.2 → NP_724828.1  hebe, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K568
      Related
      FBpp0087570
      Conserved Domains (1) summary
      PRK10811
      Location:192 → 354
      rne; ribonuclease E; Reviewed

    4. NM_165701.2 → NP_724830.1  hebe, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K568
      Related
      FBpp0087574
      Conserved Domains (1) summary
      PRK10811
      Location:192 → 354
      rne; ribonuclease E; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K568 Q7K568

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