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    HFI1 Hfi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HFI1
    Official Full Name
    Hfi1p
    Primary source
    SGD:S000006175
    Locus tag
    YPL254W
    See related
    AllianceGenome:SGD:S000006175; FungiDB:YPL254W; VEuPathDB:YPL254W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ADA1; GAN1; SRM12; SUP110
    Summary
    Enables transcription coactivator activity. Involved in chromatin organization and transcription by RNA polymerase II. Part of SAGA complex and SLIK (SAGA-like) complex. Orthologous to human TADA1 (transcriptional adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HFI1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (69485..70951)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene cyclin CLN2 Neighboring gene Bbp1p Neighboring gene Vik1p Neighboring gene adrenodoxin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Isolation and characterization of new nuclear srm gene mutation causing coordinated changes in the maintenance of nuclear and mitochondrial genetic structures in the yeast Saccharomyces]. Devin AB, et al. Genetika, 1994 Sep. PMID 8001802
    2. Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Berger SL, et al. Cell, 1992 Jul 24. PMID 1638630
    3. Differing SAGA module requirements for NCR-sensitive gene transcription in yeast. Georis I, et al. Yeast, 2024 Apr. PMID 37357465
    4. [Participation of SRM5/CDC28, SRM8/NET1, and SRM12/HFI1 genes in checkpoint control in yeast Saccharomyces cerevisiae]. Kadyshevskaia EIu, et al. Genetika, 2009 Apr. PMID 19507699
    5. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. Gangloff YG, et al. Mol Cell Biol, 2000 Jan. PMID 10594036, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA-type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hfi1p
    NP_015069.1
    • Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      69485..70951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184068.1 → NP_015069.1  TPA: Hfi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3B7, O00039, Q02813, Q12060
      UniProtKB/TrEMBL
      A6ZW02, B3LKH8, B5VST3, C7GTR1, C8ZIC4, N1NVY2
      Conserved Domains (1) summary
      pfam12767
      Location:60 → 316
      SAGA-Tad1; Transcriptional regulator of RNA polII, SAGA, subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12060.1

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