THI21 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: THI21
Official Full Name: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
Primary source: SGD:S000006179
Locus tag: YPL258C
See related: AllianceGenome:SGD:S000006179; FungiDB:YPL258C; VEuPathDB:YPL258C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables hydroxymethylpyrimidine kinase activity and phosphomethylpyrimidine kinase activity. Involved in thiamine biosynthetic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See THI21 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (53498..55153, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydroxymethylpyrimidine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxymethylpyrimidine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydroxymethylpyrimidine kinase activity	IEA Inferred from Electronic Annotation more info
enables hydroxymethylpyrimidine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphomethylpyrimidine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphomethylpyrimidine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphomethylpyrimidine kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphomethylpyrimidine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables thiaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in thiamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase

NP_015065.1

EC 2.7.1.49

EC 2.7.4.7

Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

53498..55153 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184072.1 → NP_015065.1 TPA: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015065.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3B1, Q08975

UniProtKB/TrEMBL

B3LKH4, C7GSG0, G2WNS7, N1NVG8

Conserved Domains (2) summary

COG0351
Location:22 → 298

ThiD; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]

COG0819
Location:331 → 551

TenA; Thiaminase [Coenzyme transport and metabolism]