Btk Bruton tyrosine kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Btkprovided by FlyBase
Official Full Name: Bruton tyrosine kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0003502
Locus tag: Dmel_CG8049
See related: AllianceGenome:FB:FBgn0003502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: btk; btk29; Btk29; btk29a; btk29A; Btk29a; Btk29A; c-src/fps; C-src2; C-src4; CG18355; CG8049; CT2415; CT41718; Dm SRC2; Dmel\CG8049; DSrc28; Dsrc28C; dsrc29A; Dsrc29A; DTec29; EC2-9; fic; S13; SRC 29A; src-4; src2; Src2; src28C; Src29A; src4; Tec; tec29; Tec29; Tec29A
Summary: Enables protein tyrosine kinase activity. Involved in several processes, including DNA endoreduplication; determination of adult lifespan; and oogenesis. Located in several cellular components, including apical part of cell; germline ring canal; and plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; gut section; head epidermis primordium; and imaginal disc. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; lymphoma (multiple); and lymphoproliferative syndrome 1. Orthologous to several human genes including ITK (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 29A1-29A3; 2-31 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8258373..8301079, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8258373..8301079, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although Drosophila Btk is highly expressed in the fly central nervous system, there is limited information regarding its functional role(s) therein; this study demonstrates acute differential roles for this kinase within distinct mushroom body neuronal populations in the regulation of habituation dynamics to repeated footshock stimuli.
Title: Drosophila Bruton's Tyrosine Kinase Regulates Habituation Latency and Facilitation in Distinct Mushroom Body Neurons.
Study shows that Btk29A and WASH are required for luminal clearance and that Btk29A induces WASH phosphorylation propose that the WASH phosphorylation status balances F-actin assembly between the endosomal and cortical F-actin networks to regulate the timing of luminal clearance and airway shape.
Title: WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.
Btk29A is required for the establishment of egg chamber polarity presumably through the regulation of subcellular localization of its downstream proteins, including Cno.
Title: Ovarian polarity and cell shape determination by Btk29A in Drosophila.
Btk29A(ficP) mutant males null for the Btk29A type 2 isoform, a fly homolog of the nonreceptor tyrosine kinase Btk, show no courtship suppression, while Btk29A hypomorphic males exhibit a complete loss in courtship suppression within 30 min.
Title: REQUIREMENT OF THE TEC FAMILY TYROSINE KINASE BTK29A FOR COURTSHIP MEMORY IN Drosophila MALES.
dissociation of tyrosine-phosphorylated Arm from DE-cadherin allows dynamic actin to reorganize, leading to ring canal expansion and cell shape changes during the course of oogenesis
Title: Btk29A-mediated tyrosine phosphorylation of armadillo/β-catenin promotes ring canal growth in Drosophila oogenesis.
Btk29A is required non cell-autonomously for the invagination of the spiracular chamber in Drosophila
Title: Btk-dependent epithelial cell rearrangements contribute to the invagination of nearby tubular structures in the posterior spiracles of Drosophila.
this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.
Title: Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila.
role of Btk29A type 2 on a transcriptomic level in larval CNS and adult heads
Title: Differential evolutionary wiring of the tyrosine kinase Btk.
Btk29A tyrosine kinase has a role in phosphorylation and enzymatic activity of phosphoglucomutase in drosophila
Title: Enhanced phosphorylation and enzymatic activity of phosphoglucomutase by the Btk29A tyrosine kinase in Drosophila.
In the absence of its PH domain, Tec29 constitutively localizes to ring canals, but still requires Src64 for full activation
Title: Localization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	TAS Traceable Author Statement more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in courtship behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in female germline ring canal formation	IDA Inferred from Direct Assay more info	PubMed
involved_in female germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensitization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bruton tyrosine kinase

Names: Btk family kinase at 29A; Btk-PA; Btk-PB; Btk-PC; Btk-PD; Btk-PE; Btk-PF; Btk-PG; Btk-PH; Btk29A type 2; CG8049-PA; CG8049-PB; CG8049-PC; CG8049-PD; CG8049-PE; CG8049-PF; CG8049-PG; CG8049-PH; Src oncogene 29A; fickle

NP_001097120.1

EC 2.7.10.2

NP_001097121.1

EC 2.7.10.2

NP_001260243.1

EC 2.7.10.2

NP_001260244.1

EC 2.7.10.2

NP_476745.1

EC 2.7.10.2

NP_476746.1

EC 2.7.10.2

NP_723369.1

EC 2.7.10.2

NP_723370.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8258373..8301079 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103651.3 → NP_001097121.1 bruton tyrosine kinase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097121.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F3, A4V0F4, O45032, O76132, O76133, P08630, P11361, Q6NNV0, Q8T0A0, Q9VLQ2, Q9VLQ3

Conserved Domains (5) summary

cd05059
Location:521 → 778

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:403 → 505

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:346 → 399

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases

cd01238
Location:44 → 222

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

pfam07714
Location:526 → 777

Pkinase_Tyr; Protein tyrosine kinase
NM_057398.4 → NP_476746.1 bruton tyrosine kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476746.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08630

Related

FBpp0079238

Conserved Domains (3) summary

cd05059
Location:338 → 595

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:220 → 322

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:163 → 216

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases
NM_164804.2 → NP_723369.1 bruton tyrosine kinase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723369.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F3, A4V0F4, O45032, O76132, O76133, P08630, P11361, Q6NNV0, Q8T0A0, Q9VLQ2, Q9VLQ3

Related

FBpp0079237

Conserved Domains (5) summary

cd05059
Location:521 → 778

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:403 → 505

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:346 → 399

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases

cd01238
Location:44 → 222

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

pfam07714
Location:526 → 777

Pkinase_Tyr; Protein tyrosine kinase
NM_001273315.1 → NP_001260244.1 bruton tyrosine kinase, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260244.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCX8

Conserved Domains (3) summary

cd05059
Location:199 → 456

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:81 → 183

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:24 → 77

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases
NM_164805.2 → NP_723370.1 bruton tyrosine kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723370.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08630

Related

FBpp0079235

Conserved Domains (3) summary

cd05059
Location:338 → 595

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:220 → 322

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:163 → 216

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases
NM_001103650.2 → NP_001097120.1 bruton tyrosine kinase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097120.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08630

Conserved Domains (3) summary

cd05059
Location:338 → 595

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:220 → 322

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:163 → 216

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases
NM_001273314.1 → NP_001260243.1 bruton tyrosine kinase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260243.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCD8

Conserved Domains (3) summary

cd05059
Location:300 → 557

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:182 → 284

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:125 → 178

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases
NM_057397.6 → NP_476745.1 bruton tyrosine kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476745.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F3, A4V0F4, O45032, O76132, O76133, P08630, P11361, Q6NNV0, Q8T0A0, Q9VLQ2, Q9VLQ3

Related

FBpp0079236

Conserved Domains (5) summary

cd05059
Location:521 → 778

PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases

cd09934
Location:403 → 505

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:346 → 399

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases

cd01238
Location:44 → 222

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

pfam07714
Location:526 → 777

Pkinase_Tyr; Protein tyrosine kinase