norpA no receptor potential A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: norpAprovided by FlyBase
Official Full Name: no receptor potential Aprovided by FlyBase
Primary source: FLYBASE:FBgn0262738
Locus tag: Dmel_CG3620
See related: AllianceGenome:FB:FBgn0262738
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24
Summary: Enables GTPase activator activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; entrainment of circadian clock by photoperiod; and negative regulation of compound eye retinal cell programmed cell death. Located in rhabdomere. Part of inaD signaling complex. Is expressed in several structures, including Bolwig nerve; brain; organism subdivision; photoreceptor; and photoreceptor neurons. Used to study retinal degeneration and retinal disease. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4B6-4C1; 1-8 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4322626..4365408)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4216659..4259441)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guided by the structure of the INAD-NORPA complex, we discover that INADL is probably a mammalian counterpart of INAD. The INADL PDZ89 tandem specifically binds to PLCb4 with a mode that is strikingly similar to that of the INAD-NORPA complex, as revealed by the structure of the INADL PDZ89-PLCb4 CC-PBM complex.
Title: An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors.
This study demonstrated that NorpA and eya2 mutants with disrupted vision showed normal mating effects on sleep.
Title: Mechanisms of sleep plasticity due to sexual experience in Drosophila melanogaster.
These results provide evidence for the existence of a unique dPIP5K dependent pool of PIP2 required for normal Drosophila phototransduction.
Title: A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors.
The positive feedback between PLCbeta and IP3R found here may represent a common feature of the inositol-lipid signaling
Title: Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.
Taken together, these findings reveal that PLC function in Drosophila sweet-sensing neurons is a conserved molecular signaling pathway that confers attraction to fatty acids
Title: Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neurons.
This review prestnted the evidence the norpA mutation have significantly contributed to understanding the molecular and biochemical basis of phototransduction in Drosophila.
Title: Impact of studies of the Drosophila norpA mutation on understanding phototransduction.
Light reception mediated by Rh5 and Rh6 must utilize either a different (nonretinal) phospholipase C-beta enzyme or alternative signaling mechanisms, at least in terms of clock-relevant photoreception
Title: Rhodopsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster is independent of retinal phospholipase C-β signaling.
the Galphaq-PLCbeta-Ca(2+)-DUOX-ROS signaling pathway acts as a bona fide first line of defense that enables gut epithelia to dynamically control yeast during the Drosophila life cycle
Title: Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity.
Analysis of norpA inaE double mutants and severe inaE mutants defective in photoreceptor respponses to light shows that normal diacylglycerol lipase activity is required for the generation of physiologically meaningful photoreceptor responses.
Title: DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors.
loss of the norpa gene product induces massive endocytosis of rhodopsin and arrestin in photoreceptors
Title: Loss of the phospholipase C gene product induces massive endocytosis of rhodopsin and arrestin in Drosophila photoreceptors.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol phospholipase C activity	TAS Traceable Author Statement more info	PubMed
enables phospholipase C activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating opsin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in phospholipid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in phospholipid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of inaD signaling complex	IPI Inferred from Physical Interaction more info	PubMed
part_of inaD signaling complex	TAS Traceable Author Statement more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: no receptor potential A

Names: CG3620-PA; CG3620-PB; CG3620-PC; CG3620-PD; CG3620-PE; CG3620-PF; No receptor potential A; eye-specific PLC; mRNA-like ncRNA in embryogenesis 18; no receptor potential; no receptor potentials A; no-receptor potential A; no-receptor-potential A; no-receptor-potential-A; norp A; norpA-PA; norpA-PB; norpA-PC; norpA-PD; norpA-PE; norpA-PF; phospholipase C; phospholipase C-beta; phospholipase C[[beta]]; phospholipase cbeta; phospholipase-C

NP_001014720.1

EC 3.1.4.-

EC 3.1.4.11

NP_001014721.1

EC 3.1.4.-

EC 3.1.4.11

NP_001162661.1

EC 3.1.4.-

EC 3.1.4.11

NP_001284860.1

EC 3.1.4.-

EC 3.1.4.11

NP_525069.2

EC 3.1.4.-

EC 3.1.4.11

NP_726925.1

EC 3.1.4.-

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

4322626..4365408

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169190.2 → NP_001162661.1 no receptor potential A, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162661.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3Y2, P13217, Q59E70, Q86P93, Q9U4G4, Q9W4K9

UniProtKB/TrEMBL

E1JJD5

Conserved Domains (7) summary

cd00275
Location:689 → 806

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:318 → 653

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:224 → 786

PLN02952; phosphoinositide phospholipase C

cd13361
Location:17 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:866 → 908

DUF1154; Protein of unknown function (DUF1154)

pfam09074
Location:887 → 1003

Mer2; Mer2

pfam09279
Location:227 → 318

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
NM_001014720.2 → NP_001014720.1 no receptor potential A, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014720.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCI4

Conserved Domains (7) summary

cd00275
Location:689 → 806

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:318 → 653

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:224 → 786

PLN02952; phosphoinositide phospholipase C

cd13361
Location:17 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:866 → 908

DUF1154; Protein of unknown function (DUF1154)

pfam09074
Location:887 → 1003

Mer2; Mer2

pfam09279
Location:227 → 318

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
NM_167008.2 → NP_726925.1 no receptor potential A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726925.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3Y2, P13217, Q59E70, Q86P93, Q9U4G4, Q9W4K9

UniProtKB/TrEMBL

E1JJD5

Related

FBpp0070618

Conserved Domains (7) summary

cd00275
Location:689 → 806

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:318 → 653

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:224 → 786

PLN02952; phosphoinositide phospholipase C

cd13361
Location:17 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:866 → 908

DUF1154; Protein of unknown function (DUF1154)

pfam09074
Location:887 → 1003

Mer2; Mer2

pfam09279
Location:227 → 318

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
NM_001297931.1 → NP_001284860.1 no receptor potential A, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284860.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCI4

Conserved Domains (7) summary

cd00275
Location:689 → 806

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:318 → 653

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:224 → 786

PLN02952; phosphoinositide phospholipase C

cd13361
Location:17 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:866 → 908

DUF1154; Protein of unknown function (DUF1154)

pfam09074
Location:887 → 1003

Mer2; Mer2

pfam09279
Location:227 → 318

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
NM_080330.4 → NP_525069.2 no receptor potential A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525069.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3Y2, P13217, Q59E70, Q86P93, Q9U4G4, Q9W4K9

UniProtKB/TrEMBL

E1JJD5

Related

FBpp0070619

Conserved Domains (7) summary

cd00275
Location:689 → 806

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:318 → 653

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:224 → 786

PLN02952; phosphoinositide phospholipase C

cd13361
Location:17 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:866 → 908

DUF1154; Protein of unknown function (DUF1154)

pfam09074
Location:887 → 1003

Mer2; Mer2

pfam09279
Location:227 → 318

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
NM_001014721.3 → NP_001014721.1 no receptor potential A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014721.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCI4

Conserved Domains (7) summary

cd00275
Location:689 → 806

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:318 → 653

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:224 → 786

PLN02952; phosphoinositide phospholipase C

cd13361
Location:17 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:866 → 908

DUF1154; Protein of unknown function (DUF1154)

pfam09074
Location:887 → 1003

Mer2; Mer2

pfam09279
Location:227 → 318

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like