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    kar karmoisin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    karprovided by FlyBase
    Official Full Name
    karmoisinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001296
    Locus tag
    Dmel_CG12286
    See related
    AllianceGenome:FB:FBgn0001296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12286; Dmel\CG12286
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in aromatic amino acid transport. Predicted to be located in plasma membrane. Is expressed in several structures, including adult fat body; adult head; amnioserosa; somatic precursor cell; and yolk nucleus. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A10 (solute carrier family 16 member 10) and SLC16A2 (solute carrier family 16 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kar in Genome Data Viewer
    Location:
    87C5-87C5; 3-52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12682186..12689367, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8507908..8515089, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene members only Neighboring gene Cytochrome P450 313a4 Neighboring gene Suppressor of fused Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Position Effects and Variegation Enhancers in an Autosomal Region of DROSOPHILA MELANOGASTER. Henikoff S. Genetics, 1979 Sep. PMID 17248959, Free PMC Article
    2. Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study. Gupta MK, et al. Genetica, 2020 Dec. PMID 32804315
    3. Subcellular localization of the first three enzymes of the ommochrome synthetic pathway in Drosophila melanogaster. Sullivan DT, et al. J Exp Zool, 1974 May. PMID 4133038
    4. A gene responsible for a cuticular hydrocarbon polymorphism in Drosophila melanogaster. Coyne JA, et al. Genet Res, 1999 Jun. PMID 10425916
    5. The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment. Pham A, et al. Genetics, 1995 Jun. PMID 7498739, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aromatic amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    karmoisin
    Names
    CG12286-PA
    CG12286-PB
    kar-PA
    kar-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12682186..12689367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143768.3 → NP_652025.2  karmoisin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652025.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SN6, Q9VG39
      Related
      FBpp0082135
      Conserved Domains (2) summary
      cd06174
      Location:81 → 459
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:124 → 439
      MFS_1; Major Facilitator Superfamily

    2. NM_001202284.1 → NP_001189213.1  karmoisin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV48, Q95SN6
      Conserved Domains (2) summary
      cd06174
      Location:81 → 459
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:124 → 439
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C8VV48 C8VV48
    Q95SN6 Q95SN6
    Q9VG39 Q9VG39

    Gene LinkOut

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