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    Bx42 Bx42 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bx42provided by FlyBase
    Official Full Name
    Bx42provided by FlyBase
    Primary source
    FLYBASE:FBgn0004856
    Locus tag
    Dmel_CG8264
    See related
    AllianceGenome:FB:FBgn0004856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bx-42; bx42; BX42; CG8264; Dmel\CG8264; Skip; SKIP
    Summary
    Involved in embryonic development via the syncytial blastoderm and eye-antennal disc development. Part of Prp19 complex. Is expressed in embryonic/larval salivary gland; follicle cell; nurse cell; and organism. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human SNW1 (SNW domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bx42 in Genome Data Viewer
    Location:
    8C9-8C9; 1-26 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9103870..9106604, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8997903..9000637, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mir-13b-2 stem loop Neighboring gene Chaperonin containing TCP1 subunit 2 Neighboring gene uncharacterized protein Neighboring gene ADP-ribosylation factor related protein 1 Neighboring gene Adaptor Protein complex 1, gamma subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila nuclear protein Bx42, which is found in many puffs on polytene chromosomes, is highly charged. Wieland C, et al. Chromosoma, 1992 Jun. PMID 1424996
    2. Two proteins from Drosophila nuclei are bound to chromatin and are detected in a series of puffs on polytene chromosomes. Frasch M, et al. Chromosoma, 1989 Jan. PMID 2495915
    3. Two puff-specific proteins bind within the 2.5 kb upstream region of the Drosophila melanogaster Sgs-4 gene. Saumweber H, et al. Chromosoma, 1990 Apr. PMID 2160364
    4. Genetic and molecular characterization of a variegating hsp70-acZ fusion gene in the euchromatic 31 B region of Drosophila melanogaster. Morcillo P, et al. Genome, 2001 Aug. PMID 11550907
    5. Inducible RNA interference uncovers the Drosophila protein Bx42 as an essential nuclear cofactor involved in Notch signal transduction. Negeri D, et al. Mech Dev, 2002 Sep. PMID 12204255

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phenotypically the effects of Bx42 RNAi resemble those obtained for certain classes of Notch mutants, pointing to an involvement of Bx42 in the Notch signal transduction pathway.
      Title: Inducible RNA interference uncovers the Drosophila protein Bx42 as an essential nuclear cofactor involved in Notch signal transduction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye-antennal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bx42
    Names
    Bx42-PA
    Bx42-PB
    CG8264-PA
    CG8264-PB
    Ski-interacting protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9103870..9106604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272441.2 → NP_001259370.1  Bx42, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39736, Q9W390
      UniProtKB/TrEMBL
      M9PGQ6
      Conserved Domains (1) summary
      pfam02731
      Location:181 → 337
      SKIP_SNW; SKIP/SNW domain

    2. NM_078538.4 → NP_511093.2  Bx42, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511093.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39736, Q9W390
      UniProtKB/TrEMBL
      M9PGQ6
      Related
      FBpp0071285
      Conserved Domains (1) summary
      pfam02731
      Location:181 → 337
      SKIP_SNW; SKIP/SNW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGQ6 M9PGQ6
    P39736.1 P39736

    Gene LinkOut

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