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    CG2218 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2218provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039767
    Locus tag
    Dmel_CG2218
    See related
    AllianceGenome:FB:FBgn0039767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2218; UIP5
    Summary
    Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human UBOX5 (U-box domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2218 in Genome Data Viewer
    Location:
    99F4-99F4; 3-100 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30425427..30428276, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26251149..26253998, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S18C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and transcriptional profiling of differentially expressed genes associated with response to UVA radiation in Drosophila melanogaster (Diptera: Drosophilidae). Zhou LJ, et al. Environ Entomol, 2013 Oct. PMID 24331622
    2. Ancient origin of animal U-box ubiquitin ligases. Marín I. BMC Evol Biol, 2010 Oct 27. PMID 20979629, Free PMC Article
    3. Close head-to-head juxtaposition of genes favors their coordinate regulation in Drosophila melanogaster. Herr DR, et al. FEBS Lett, 2004 Aug 13. PMID 15304339
    4. The Wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster. Fear JM, et al. BMC Syst Biol, 2015 Sep 4. PMID 26335107, Free PMC Article
    5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    BT044264.1
    CG2218-PA
    CG2218-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30425427..30428276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143533.3 → NP_651790.1  uncharacterized protein Dmel_CG2218, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH93, Q9VA79
      Related
      FBpp0084991
      Conserved Domains (1) summary
      pfam04564
      Location:222 → 300
      U-box; U-box domain

    2. NM_001300684.1 → NP_001287613.1  uncharacterized protein Dmel_CG2218, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH93, Q9VA79
      Conserved Domains (1) summary
      pfam04564
      Location:222 → 300
      U-box; U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IH93 Q8IH93
    Q95TR9 Q95TR9
    Q9VA79 Q9VA79

    Gene LinkOut

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