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    wapl wings apart-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    waplprovided by FlyBase
    Official Full Name
    wings apart-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004655
    Locus tag
    Dmel_CG3707
    See related
    AllianceGenome:FB:FBgn0004655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C204; CG3707; Dmel\CG3707; EG:87B1.2; l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2; pasc; RNA D; RNAD; wap; Wapl; WAPL
    Summary
    Enables cohesin unloader activity. Involved in chromatin organization and sister chromatid cohesion. Located in chromatin and nucleus. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wapl in Genome Data Viewer
    Location:
    2D4-2D5; 1-0.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2149936..2158983, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2043969..2053016, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene D-2-hydroxyglutaric acid dehydrogenase Neighboring gene Phosphogluconate dehydrogenase Neighboring gene bcn92 Neighboring gene Cytochrome P450 4d1 Neighboring gene uncharacterized protein Neighboring gene mir-3641 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Controlling the false-positive rate in multilocus genome scans for selection. Thornton KR, et al. Genetics, 2007 Feb. PMID 17110489, Free PMC Article
    2. [Trans-effect of modifiers on position-effect variegation in a set of euchromatin-heterochromatin rearrangements in Drosophila melanogaster]. Popkova AM, et al. Genetika, 2001 Oct. PMID 11761621
    3. Inferring selection in partially sequenced regions. Jensen JD, et al. Mol Biol Evol, 2008 Feb. PMID 18165259
    4. The size and internal structure of a heterochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster. Tolchkov EV, et al. Genetics, 2000 Apr. PMID 10747057, Free PMC Article
    5. Molecular characterization of the breakpoints of an inversion fixed between Drosophila melanogaster and D. subobscura. Cirera S, et al. Genetics, 1995 Jan. PMID 7705632, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings suggests that the mutant Wapl-AG might exert its effects through changes in cohesin binding; Wapl-AG was found to increase the stability of cohesin binding to polytene chromosomes
      Title: Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila.
    2. Study shows that DNA replication and cohesin acetylation promote binding of Sororin to cohesin, and that Sororin displaces Wapl from its binding partner Pds5; in the absence of Wapl, Sororin becomes dispensable for cohesion.
      Title: Sororin mediates sister chromatid cohesion by antagonizing Wapl.
    3. Nipped-B, Pds5, and the Wapl protein that interacts with Pds5 all play unique roles in cohesin chromosome binding.
      Title: Dosage-sensitive regulation of cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cohesin unloader activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wings apart-like
    Names
    CG3707-PA
    CG3707-PB
    CG3707-PC
    parallel sister chromatids protein
    wapl-PA
    wapl-PB
    wapl-PC
    wings-apart-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2149936..2158983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297875.1 → NP_001284804.1  wings apart-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46095, Q24153, Q7KVZ8, Q8MRI2, Q9W517, Q9W518
      UniProtKB/TrEMBL
      A0A0F6QCC2, X2JAA8
      Conserved Domains (1) summary
      pfam07814
      Location:1152 → 1515
      WAPL; Wings apart-like protein regulation of heterochromatin

    2. NM_080303.3 → NP_525042.2  wings apart-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525042.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46095, Q24153, Q7KVZ8, Q8MRI2, Q9W517, Q9W518
      UniProtKB/TrEMBL
      A0A0F6QCC2, X2JAA8
      Related
      FBpp0070413
      Conserved Domains (1) summary
      pfam07814
      Location:1152 → 1515
      WAPL; Wings apart-like protein regulation of heterochromatin

    3. NM_166931.2 → NP_726796.2  wings apart-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726796.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0F6QB41, A0A0F6QB50
      Related
      FBpp0070414
      Conserved Domains (1) summary
      pfam07814
      Location:503 → 866
      WAPL; Wings apart-like protein regulation of heterochromatin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W517.1 Q9W517
    X2JAA8 X2JAA8

    Gene LinkOut

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