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    M7BP Myosin-7a binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35698, updated on 9-Dec-2024

    Summary

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    Official Symbol
    M7BPprovided by FlyBase
    Official Full Name
    Myosin-7a binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263077
    Locus tag
    Dmel_CG43340
    See related
    AllianceGenome:FB:FBgn0263077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02712; BcDNA:HL07907; CG17983; CG17984; CG2080; CG2088; CG30492; CG30494; CG43340; CT6764; Dmel\CG43340
    Old locus tag
    Dmel_CG30492; Dmel_CG30494
    Summary
    Enables ATPase activator activity and myosin binding activity. Involved in filopodium assembly. Located in cytosol. Colocalizes with actin cytoskeleton. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See M7BP in Genome Data Viewer
    Location:
    43E5-43E7; 2-57 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7623242..7651787)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3510747..3539292)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Histamine transporter Neighboring gene long non-coding RNA:CR44444 Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A binding protein regulates myosin-7a dimerization and actin bundle assembly. Liu R, et al. Nat Commun, 2021 Jan 25. PMID 33495456, Free PMC Article
    2. Genetic screen for genes involved in Chk2 signaling in Drosophila. Park SY, et al. Mol Cells, 2008 Oct 31. PMID 18612247
    3. Control of daily transcript oscillations in Drosophila by light and the circadian clock. Wijnen H, et al. PLoS Genet, 2006 Mar. PMID 16565745, Free PMC Article
    4. Gene-by-temperature interactions and candidate plasticity genes for morphological traits in Drosophila melanogaster. Carreira VP, et al. PLoS One, 2013. PMID 23936253, Free PMC Article
    5. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in filopodium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Myosin-7a binding protein
    Names
    CG43340-PA
    CG43340-PC
    CG43340-PD
    CG43340-PE
    CG43340-PF
    CG43340-PG
    CG43340-PH
    CG43340-PJ
    CG43340-PK
    CG43340-PL
    CG43340-PM
    CG43340-PN
    CG43340-PO
    CG43340-PP
    CG43340-PQ
    M7BP-PA
    M7BP-PC
    M7BP-PD
    M7BP-PE
    M7BP-PF
    M7BP-PG
    M7BP-PH
    M7BP-PJ
    M7BP-PK
    M7BP-PL
    M7BP-PM
    M7BP-PN
    M7BP-PO
    M7BP-PP
    M7BP-PQ
    myosin-7a binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7623242..7651787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259256.2 → NP_001246185.1  Myosin-7a binding protein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246185.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z718, Q8MQX7
      Conserved Domains (1) summary
      cd15751
      Location:100 → 156
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    2. NM_176100.2 → NP_788280.1  Myosin-7a binding protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788280.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z718, Q8MQX7
      Conserved Domains (1) summary
      cd15751
      Location:100 → 156
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    3. NM_001103740.3 → NP_001097210.2  Myosin-7a binding protein, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097210.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY53, F3YDQ1
      Conserved Domains (1) summary
      cd15751
      Location:100 → 156
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    4. NM_176101.3 → NP_788281.1  Myosin-7a binding protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z719, F3YDQ1
      Conserved Domains (1) summary
      cd15751
      Location:100 → 156
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    5. NM_170613.3 → NP_724586.2  Myosin-7a binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724586.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z720, Q8MQX7
      Conserved Domains (1) summary
      cd15751
      Location:63 → 119
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    6. NM_170614.3 → NP_724587.2  Myosin-7a binding protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724587.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z720, Q8MQX7
      Conserved Domains (1) summary
      cd15751
      Location:63 → 119
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    7. NM_001273853.1 → NP_001260782.1  Myosin-7a binding protein, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU21, Q95R83
      Conserved Domains (1) summary
      cd15751
      Location:63 → 119
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    8. NM_001259255.1 → NP_001246184.1  Myosin-7a binding protein, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U0
      Conserved Domains (1) summary
      cd15751
      Location:63 → 119
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    9. NM_001259257.1 → NP_001246186.1  Myosin-7a binding protein, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246186.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K702
      Conserved Domains (1) summary
      cd15751
      Location:63 → 119
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    10. NM_136458.3 → NP_610302.3  Myosin-7a binding protein, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610302.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z722
      Conserved Domains (1) summary
      cd15751
      Location:63 → 119
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    11. NM_001259258.2 → NP_001246187.1  Myosin-7a binding protein, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z721, Q95R83
      Conserved Domains (1) summary
      PHA03307
      Location:441 → 611
      PHA03307; transcriptional regulator ICP4; Provisional

    12. NM_001259259.2 → NP_001246188.1  Myosin-7a binding protein, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z721, Q95R83
      Conserved Domains (1) summary
      PHA03307
      Location:441 → 611
      PHA03307; transcriptional regulator ICP4; Provisional

    13. NM_001259260.1 → NP_001246189.1  Myosin-7a binding protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U2, D0Z771
      Conserved Domains (1) summary
      PHA03307
      Location:565 → 735
      PHA03307; transcriptional regulator ICP4; Provisional

    14. NM_176102.3 → NP_788282.1  Myosin-7a binding protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788282.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z721, Q95R83
      Conserved Domains (1) summary
      PHA03307
      Location:441 → 611
      PHA03307; transcriptional regulator ICP4; Provisional

    15. NM_001273854.1 → NP_001260783.1  Myosin-7a binding protein, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEE5
      Conserved Domains (2) summary
      PRK10811
      Location:1920 → 2090
      rne; ribonuclease E; Reviewed
      PRK14949
      Location:1360 → 1738
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K702 A0A0B4K702
    A0A0B4K7U0 A0A0B4K7U0
    A0A0B4K7U2 A0A0B4K7U2
    A0A0B4KEE5 A0A0B4KEE5
    A1Z718 A1Z718
    A1Z719 A1Z719
    A1Z720 A1Z720
    A1Z721 A1Z721
    A1Z722 A1Z722
    A8DY53 A8DY53
    G4LU21 G4LU21

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