Rpt2 Regulatory particle triple-A ATPase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpt2provided by FlyBase
Official Full Name: Regulatory particle triple-A ATPase 2provided by FlyBase
Primary source: FLYBASE:FBgn0015282
Locus tag: Dmel_CG5289
See related: AllianceGenome:FB:FBgn0015282
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5289; CG5289; Dm-S4-1; Dmel\CG5289; DmP26S4; Dm_Rpt2; dRpt2; P26s4; p56; pros26.4; Pros26.4; PSMC1; rpt2; S4
Summary: Predicted to enable proteasome-activating activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, base subcomplex. Is expressed in several structures, including adult head; amnioserosa; ganglia; germline cell; and imaginal disc. Used to study Parkinson's disease; neurodegenerative disease; and neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95C13-95C13; 3-81 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23929873..23931558, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19755595..19757280, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lethal phenotype of Dsk2 overexpression could be rescued in a double transgenic line coexpressing Flag-Dsk2 and Flag-p54. Although the double transgenic line was viable and fertile, it did not restore the proteolytic defects.
Title: Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit.
Data show that Pros26.4 negatively regulates Hairless at the genetic and molecular level, providing a novel mechanism of positive regulation of Notch signalling.
Title: A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome-activating activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: regulatory particle triple-A ATPase 2

Names: 26S proteasome subunit 4 ATPase; CG5289-PA; CG5289-PB; Rpt2-PA; Rpt2-PB; proteasome 26S; proteasome 26S subunit 4 ATPase; proteasome 26S subunit subunit 4 ATPase

NP_001287493.1

EC 5.6.1.5

NP_524469.2

EC 5.6.1.5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23929873..23931558 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300564.1 → NP_001287493.1 regulatory particle triple-A ATPase 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287493.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48601, Q9VCG1

UniProtKB/TrEMBL

A0A0B4LIJ0

Conserved Domains (1) summary

PTZ00361
Location:1 → 439

PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional
NM_079745.4 → NP_524469.2 regulatory particle triple-A ATPase 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524469.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P48601, Q9VCG1

UniProtKB/TrEMBL

A0A0B4LIJ0

Related

FBpp0083906

Conserved Domains (1) summary

PTZ00361
Location:1 → 439

PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional