U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    boss bride of sevenless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43146, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bossprovided by FlyBase
    Official Full Name
    bride of sevenlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000206
    Locus tag
    Dmel_CG8285
    See related
    AllianceGenome:FB:FBgn0000206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bos; Boss; BOSS; CG8285; Dmel\CG8285; F; X55887
    Summary
    Enables receptor ligand activity and sevenless binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; germ-line stem-cell niche homeostasis; and response to glucose. Located in rhabdomere microvillus membrane. Is expressed in several structures, including adult head; embryonic/larval fat body; eye photoreceptor cell; imaginal disc; and mystery cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See boss in Genome Data Viewer
    Location:
    96F8-96F8; 3-89 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25961994..25966948)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21787716..21792670)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR34024 Neighboring gene Crustacean cardioactive peptide receptor Neighboring gene uncharacterized protein Neighboring gene fire dancer Neighboring gene Neurofibromin 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development. Reinke R, et al. Cell, 1988 Oct 21. PMID 3167983
    2. The Drosophila 7-pass transmembrane glycoprotein BOSS and metabolic regulation: What Drosophila can teach us about human energy metabolism. Kohyama-Koganeya A, et al. Methods Enzymol, 2010. PMID 20816226
    3. Sevenless and its bride: a marriage of molecules? Tomlinson A. Curr Biol, 1991 Jun. PMID 15336144
    4. The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cagan RL, et al. Cell, 1992 May 1. PMID 1316239
    5. Fast co-evolution of sevenless and bride of sevenless in endopterygote insects. Bao R, et al. Dev Genes Evol, 2008 Apr. PMID 18392882

    See all (307) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BOSS affects lifespan by modulating the expression of a set of genes related to oxidative stress resistance and mitochondrial homeostasis
      Title: Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila.
    2. summary of the utility of Drosophila as a model organism for studying conserved mechanisms of glucose and triacylglycerol (energy) homeostatic metabolism through the 7-pass transmembrane glycoprotein BOSS, which carries N-linked carbohydrates.
      Title: The Drosophila 7-pass transmembrane glycoprotein BOSS and metabolic regulation: What Drosophila can teach us about human energy metabolism.
    3. BOSS, responds to extracellular glucose and regulates sugar and lipid metabolism.
      Title: A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism.
    4. Possibility of conserved Sevenless signaling controlled patterning processes in endopterygote insects.
      Title: Fast co-evolution of sevenless and bride of sevenless in endopterygote insects.
    5. Sev is activated by a ligand, Bride of sevenless (Boss), which is expressed by the germline, to prevent ectopic niche differentiation in the posterior gonadal somatic cells
      Title: Boss/Sev signaling from germline to soma restricts germline-stem-cell-niche formation in the anterior region of Drosophila male gonads.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sevenless binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sevenless binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sevenless binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in R7 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R8 cell-mediated photoreceptor organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rhabdomere microvillus membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    bride of sevenless
    Names
    CG8285-PA
    F transcript
    boss-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25961994..25966948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080709.3 → NP_542440.1  bride of sevenless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_542440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22815, Q9VBJ5
      UniProtKB/TrEMBL
      C4XVJ6, Q8MSJ2
      Related
      FBpp0084323, FBtr0084949
      Conserved Domains (1) summary
      pfam00003
      Location:692 → 779
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22815.3 P22815
    Q24265 Q24265
    Q8MSJ2 Q8MSJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools