hry hairy [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hryprovided by FlyBase
Official Full Name: hairyprovided by FlyBase
Primary source: FLYBASE:FBgn0001168
Locus tag: Dmel_CG6494
See related: AllianceGenome:FB:FBgn0001168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 8247; bHLHb39; bHLHc14; brr; CG6494; dDr1; Dmel\CG6494; h; H; Hairy; HRY; l(3)08247; l(3)rM384
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; response to hypoxia; and salivary gland morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including adult CNS glial cell; anal pad; germ layer; gut section; and imaginal disc. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66D10-66D10; 3-26 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8675759..8679253)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8668859..8672353)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

argue that the role emc, h and sr in development of the flight apparatus preceded their activities for macrochaete patterning
Title: The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera.
These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete.
Title: The role of the bHLH protein hairy in morphogenetic furrow progression in the developing Drosophila eye.
Hairy induces widespread histone deacetylation and inhibits the recruitment of basal machinery without inducing chromatin compaction.
Title: Long- and short-range transcriptional repressors induce distinct chromatin states on repressed genes.
In this study, the authors show that Dgrn is a negative regulator of the repressor Hairy and its corepressor Groucho (Gro/transducin-like enhancer (TLE)) during embryonic segmentation and neurogenesis.
Title: Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression.
Studies demonstrate a novel role for Hairy in restriction of the terminal cell fate by limiting the domain of bnl expression in surrounding muscle cells such that only a single dorsal branch cell becomes specified as a terminal cell.
Title: The bHLH transcription factor, hairy, refines the terminal cell fate in the Drosophila embryonic trachea.
Results show that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular differentiation in response to the hormone.
Title: Genomic mapping of binding regions for the Ecdysone receptor protein complex.
hypoxia-selected flies: (a) altered their gene expression and genetic code, and (b) coordinated their metabolic suppression, especially during development, with hairy acting as a metabolic switch, thus playing a crucial role in hypoxia-tolerance
Title: Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch.
These studies suggest that protein kinase CK2 contributes to repression by Hairy.
Title: Drosophila CK2 phosphorylates Hairy and regulates its activity in vivo.
long-range effects may be mediated by a "spreading" mechanism, modifying chromatin over extensive regions to inhibit transcription
Title: Spreading of a corepressor linked to action of long-range repressor hairy.
Data show that a 121-nucleotide element within the 3'-untranslated region of hairy is necessary and sufficient to mediate apical transport.
Title: The Drosophila hairy RNA localization signal modulates the kinetics of cytoplasmic mRNA transport.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0105 (e-PCR)
- UniSTS:51327

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane organization	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in periodic partitioning by pair rule gene	TAS Traceable Author Statement more info	PubMed
involved_in posterior head segmentation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trunk segmentation	TAS Traceable Author Statement more info	PubMed
involved_in tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: hairy

Names: CG6494-PA; CG6494-PB; barrel; hry-PA; hry-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8675759..8679253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014577.2 → NP_001014577.1 hairy, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014577.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1N7, P14003, Q95NH3, Q95NU9, Q9VSN8

Conserved Domains (2) summary

smart00511
Location:106 → 141

ORANGE; Orange domain

cd00083
Location:29 → 88

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_079253.4 → NP_523977.2 hairy, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523977.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1N7, P14003, Q95NH3, Q95NU9, Q9VSN8

Related

FBpp0076296

Conserved Domains (2) summary

smart00511
Location:106 → 141

ORANGE; Orange domain

cd00083
Location:29 → 88

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...