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    E(spl)malpha-BFM Enhancer of split malpha, Bearded family member [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E(spl)malpha-BFMprovided by FlyBase
    Official Full Name
    Enhancer of split malpha, Bearded family memberprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002732
    Locus tag
    Dmel_CG8337
    See related
    AllianceGenome:FB:FBgn0002732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8337; DmelCG8337; Dmel\CG8337; E(spl) malpha; E(spl)ma; E(spl)malpha; E(spl)mmalpha; HLHmalpha; malpha
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ development. Is expressed in several structures, including anterior-posterior compartment boundary of the wing disc; epithelium; eye disc posterior to the morphogenetic furrow; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E(spl)malpha-BFM in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26010893..26011568)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21836615..21837290)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Enhancer of split mbeta, helix-loop-helix Neighboring gene long non-coding RNA:CR45039 Neighboring gene long non-coding RNA:CR45040 Neighboring gene Kazal-type protease inhibitor m1 Neighboring gene Enhancer of split m2, Bearded family member

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules. Liu F, et al. PLoS Genet, 2012 Jul. PMID 22792075, Free PMC Article
    2. New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP. Barolo S, et al. Biotechniques, 2004 Mar. PMID 15038159
    3. A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects. Gagliani EK, et al. PLoS Genet, 2022 Aug. PMID 35951645, Free PMC Article
    4. Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized. Miller SW, et al. PLoS Genet, 2018 Jul. PMID 30028887, Free PMC Article
    5. Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila. Perez-Mockus G, et al. Nat Commun, 2017 Nov 17. PMID 29150614, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of split malpha, bearded family member
    Names
    CG8337-PA
    E(spl) region transcript malpha
    E(spl)malpha
    E(spl)malpha-BFM-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26010893..26011568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079782.3 → NP_524506.1  enhancer of split malpha, bearded family member [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6W7, O97178, Q56MK8, Q56MK9, Q56ML2, Q56ML4, Q56MM3, Q56MM6, Q56MN5, Q56MP7, Q56MQ1, Q56MQ4, Q56MT0, Q5S4K2
      UniProtKB/TrEMBL
      A0A1B2AKK5
      Related
      FBpp0084330
      Conserved Domains (1) summary
      pfam15952
      Location:1 → 138
      ESM4; Enhancer of split M4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97178.1 O97178

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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