U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LysE Lysozyme E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38128, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LysEprovided by FlyBase
    Official Full Name
    Lysozyme Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004428
    Locus tag
    Dmel_CG1180
    See related
    AllianceGenome:FB:FBgn0004428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP07339; CG1180; Dmel\CG1180; Lys E; lysE
    Summary
    Predicted to enable lysozyme activity. Involved in defense response to Gram-negative bacterium and negative regulation of innate immune response. Predicted to be located in extracellular space. Is expressed in adult midgut and embryonic/larval midgut. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LysE in Genome Data Viewer
    Location:
    61F3-61F3; 3-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1212827..1213406)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1212827..1213406)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene multiple wing hairs Neighboring gene Lysozyme B Neighboring gene Lysozyme C Neighboring gene Lysozyme D Neighboring gene Lysozyme P Neighboring gene Lysozyme S

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract. Daffre S, et al. Mol Gen Genet, 1994 Jan. PMID 8159165
    2. Insect lysozymes. Hultmark D. EXS, 1996. PMID 8765296
    3. Molecular adaptation of Drosophila melanogaster lysozymes to a digestive function. Regel R, et al. Insect Biochem Mol Biol, 1998 May-Jun. PMID 9692234
    4. Drosophila C virus systemic infection leads to intestinal obstruction. Chtarbanova S, et al. J Virol, 2014 Dec. PMID 25253354, Free PMC Article
    5. The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation. Yan J, et al. Genetics, 2008 Sep. PMID 18723886, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysozyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of innate immune response HMP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lysozyme E
    Names
    CG1180-PA
    LysE-PA
    NP_476827.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1212827..1213406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057479.3 → NP_476827.2  lysozyme E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476827.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C9QP86, P37159, Q8MS67, Q9W0J5
      Related
      FBpp0072526
      Conserved Domains (1) summary
      pfam00062
      Location:19 → 139
      Lys; C-type lysozyme/alpha-lactalbumin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37159.2 P37159

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous