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    Hnf4 Hepatocyte nuclear factor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnf4provided by FlyBase
    Official Full Name
    Hepatocyte nuclear factor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0004914
    Locus tag
    Dmel_CG9310
    See related
    AllianceGenome:FB:FBgn0004914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9310; dHNF-4; dHnf4; dHNF4; Dmel\CG9310; DmHNF4; Hnf-4; HNF-4; HNF-4(D); Hnf-4h; hnf4; HNF4; HNF4alpha; NHF4; NR2A4
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in several processes, including cellular response to insulin stimulus; glucose homeostasis; and lipid oxidation. Located in nucleus. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut primordium; epithelium; gut section; and oenocyte. Used to study Fanconi syndrome; maturity-onset diabetes of the young; and maturity-onset diabetes of the young type 1. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to several human genes including HNF4A (hepatocyte nuclear factor 4 alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Hnf4 in Genome Data Viewer
    Location:
    29E4-29E4; 2-33 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8687226..8709611, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8687226..8709611, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Prenyl-binding protein Neighboring gene TRAPP subunit 23 Neighboring gene antisense RNA:CR44992 Neighboring gene Catalase B Neighboring gene raw Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut. Vonolfen MC, et al. Cell Rep, 2024 Sep 24. PMID 39235946
    2. dHNF4 regulates lipid homeostasis and oogenesis in Drosophila melanogaster. Almeida-Oliveira F, et al. Insect Biochem Mol Biol, 2021 Jun. PMID 33753225
    3. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. Zhong W, et al. EMBO J, 1993 Feb. PMID 8440243, Free PMC Article
    4. Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4. Sun J, et al. Sci Adv, 2023 Jun 30. PMID 37390217, Free PMC Article
    5. Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants. Bülow MH, et al. Mol Biol Cell, 2018 Feb 15. PMID 29282281, Free PMC Article

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut.
      Title: Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut.
    2. Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
      Title: Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
    3. dHNF4 regulates lipid homeostasis and oogenesis in Drosophila melanogaster.
      Title: dHNF4 regulates lipid homeostasis and oogenesis in Drosophila melanogaster.
    4. Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A.
      Title: Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A.
    5. establish dHNF4 as a regulator of the adult metabolic state
      Title: Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.
    6. Here the authors report that loss of Drosophila HNF4 recapitulates hallmark symptoms of Maturity Onset Diabetes of the Young 1 (MODY1), including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin secretion (GSIS).
      Title: The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults.
    7. Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.
      Title: Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
    8. Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.
      Title: Drosophila HNF4 regulates lipid mobilization and beta-oxidation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 4
    Names
    CG9310-PA
    CG9310-PB
    CG9310-PD
    CG9310-PE
    CG9310-PF
    Hnf4-PA
    Hnf4-PB
    Hnf4-PD
    Hnf4-PE
    Hnf4-PF
    hepatocyte nuclear factor 4 homologue

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8687226..8709611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164834.2 → NP_723414.2  hepatocyte nuclear factor 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723414.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYX8, C5WLN3, P49866, Q8IGG2, Q8IPF2, Q9VLI7, Q9VLI8
      Conserved Domains (2) summary
      cd06931
      Location:236 → 466
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:142 → 217
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    2. NM_057539.5 → NP_476887.2  hepatocyte nuclear factor 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476887.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYX8, C5WLN3, P49866, Q8IGG2, Q8IPF2, Q9VLI7, Q9VLI8
      Related
      FBpp0079349
      Conserved Domains (2) summary
      cd06931
      Location:236 → 466
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:142 → 217
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    3. NM_001103656.3 → NP_001097126.1  hepatocyte nuclear factor 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097126.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49866
      Conserved Domains (2) summary
      cd06931
      Location:240 → 470
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:146 → 221
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    4. NM_001298829.1 → NP_001285758.1  hepatocyte nuclear factor 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9X1
      Conserved Domains (2) summary
      cd06931
      Location:198 → 428
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:104 → 179
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    5. NM_164833.2 → NP_723413.1  hepatocyte nuclear factor 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49866
      Related
      FBpp0079350
      Conserved Domains (2) summary
      cd06931
      Location:264 → 494
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:170 → 245
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49866.3 P49866
    X2J9X1 X2J9X1

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