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    Rox8 Rox8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rox8provided by FlyBase
    Official Full Name
    Rox8provided by FlyBase
    Primary source
    FLYBASE:FBgn0005649
    Locus tag
    Dmel_CG5422
    See related
    AllianceGenome:FB:FBgn0005649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5422; Dmel\CG5422; DmTIAR; dTIAR; Rbp12; Rox-8; rox8; ROX8; rrm12; RRM12; TIAR
    Summary
    Enables mRNA 3'-UTR binding activity and protein-RNA adaptor activity. Involved in several processes, including negative regulation of organ growth; positive regulation of hippo signaling; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of U1 snRNP. Is expressed in several structures, including adult head; central brain primordium; cuboidal/columnar epithelium; germline cell; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to several human genes including TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rox8 in Genome Data Viewer
    Location:
    95D9-95D10; 3-82 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24043056..24048265, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19868778..19873987, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Methyltransferase like 3 Neighboring gene Mitochondrial Rho Neighboring gene spastin Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 6 Neighboring gene Phosphatidylserine decarboxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of synaptic Pumilio function by an aggregation-prone domain. Salazar AM, et al. J Neurosci, 2010 Jan 13. PMID 20071514, Free PMC Article
    2. The developmentally-regulated Drosophila gene rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins. Brand S, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8396236, Free PMC Article
    3. Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy. Brand SF, et al. Gene, 1995 Mar 10. PMID 7890163
    4. Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. Sherwood NT, et al. PLoS Biol, 2004 Dec. PMID 15562320, Free PMC Article
    5. Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies. Khalil B, et al. Neurobiol Aging, 2017 Jun. PMID 28324764

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-RNA adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of miRNA-mediated gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rox8
    Names
    CG5422-PB
    CG5422-PC
    CG5422-PD
    CG5422-PE
    CG5422-PG
    CG5422-PH
    RNA-binding protein 12
    Rox8-PB
    Rox8-PC
    Rox8-PD
    Rox8-PE
    Rox8-PG
    Rox8-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24043056..24048265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170119.2 → NP_732945.1  Rox8, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMX4, Q8SZP5
      Related
      FBpp0083976
      Conserved Domains (4) summary
      cd12352
      Location:9 → 80
      RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12353
      Location:96 → 170
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:221 → 294
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
      TIGR01661
      Location:5 → 274
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_170116.2 → NP_732942.1  Rox8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q08212, Q9VCE3
      Related
      FBpp0083977
      Conserved Domains (4) summary
      cd12352
      Location:9 → 80
      RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12353
      Location:96 → 170
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:221 → 294
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
      TIGR01661
      Location:5 → 274
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. NM_170117.2 → NP_732943.1  Rox8, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q08212, Q9VCE3
      Related
      FBpp0083979
      Conserved Domains (4) summary
      cd12352
      Location:9 → 80
      RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12353
      Location:96 → 170
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:221 → 294
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
      TIGR01661
      Location:5 → 274
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. NM_001275969.1 → NP_001262898.1  Rox8, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMX4, Q8SZP5
      Conserved Domains (4) summary
      cd12352
      Location:9 → 80
      RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12353
      Location:96 → 170
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:221 → 294
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
      TIGR01661
      Location:5 → 274
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    5. NM_001275968.1 → NP_001262897.1  Rox8, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMX4, Q8SZP5
      Conserved Domains (4) summary
      cd12352
      Location:9 → 80
      RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12353
      Location:96 → 170
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:221 → 294
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
      TIGR01661
      Location:5 → 274
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    6. NM_170118.2 → NP_732944.2  Rox8, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732944.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMX4, Q8SZP5
      Conserved Domains (4) summary
      cd12352
      Location:9 → 80
      RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12353
      Location:96 → 170
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:221 → 294
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
      TIGR01661
      Location:5 → 274
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08212 Q08212
    Q26281 Q26281
    Q8IMX4 Q8IMX4
    Q8SZP5 Q8SZP5
    Q9VCE3 Q9VCE3

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