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    CanA1 Calcineurin A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CanA1provided by FlyBase
    Official Full Name
    Calcineurin A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010015
    Locus tag
    Dmel_CG1455
    See related
    AllianceGenome:FB:FBgn0010015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Can; CaN; CAN A1/PP2B; canA; canA1; Cana1; CaNA1; CG1455; CnA; CNA1; CnnA21EF; D14; DmCanA1-100B; Dmel\CG1455; pMY4; PP2B; PP2B 21EF; PpD14
    Summary
    Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including medium-term memory; negative regulation of epidermal growth factor receptor signaling pathway; and response to Gram-negative bacterium. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in aortic valve stenosis and schizophrenia. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CanA1 in Genome Data Viewer
    Location:
    100B1-100B1; 3-102 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31039374..31046821)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26865096..26872543)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 7 Neighboring gene long non-coding RNA:CR46117 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene mir-4948 stem loop Neighboring gene Alkaline phosphatase 4 Neighboring gene Coiled-coil-helix-coiled-coil-helix domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster. Holvoet H, et al. Nutrients, 2023 Sep 16. PMID 37764799, Free PMC Article
    2. Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin. Guerini D, et al. J Biol Chem, 1992 Nov 5. PMID 1331060
    3. Identification of a cDNA encoding a Drosophila calcium/calmodulin regulated protein phosphatase, which has its most abundant expression in the early embryo. Brown L, et al. FEBS Lett, 1994 Feb 14. PMID 8313960
    4. Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis. Habernig L, et al. PLoS Genet, 2021 Nov. PMID 34780474, Free PMC Article
    5. Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. Cardenas ME, et al. EMBO J, 1995 Jun 15. PMID 7540976, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of Ca[2+] phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
      Title: Activation of Ca(2+) phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
    2. Ca2+ administration prevents alpha-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
      Title: Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
    3. Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
      Title: Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
    4. results suggest a key role for calcineurin in cardiac remodeling during long-term hypoxia with implications for diseases of chronic hypoxia, and it likely contributes to mechanisms underlying these disease states.
      Title: Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila.
    5. upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD.
      Title: Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.
    6. results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation.
      Title: Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster.
    7. calcineurin, upon activation by Ca(2+)-calmodulin, cooperates with other factors to negatively regulate Egf receptor signaling at the level of sprouty and the GTPase-activating protein Gap1
      Title: The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 31045753-31045869 mobile_element_type = transposon:INE-1{}3519

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in medium-term memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nitric oxide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of calcineurin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcineurin A1
    Names
    CG1455-PA
    CG1455-PB
    CG1455-PD
    CanA1-PA
    CanA1-PB
    CanA1-PD
    calcineurin
    calcineurin A
    protein phosphatase D14
    protein phosphatase from PCR fragment D14
    NP_001247377.1
    NP_001247378.2
    NP_524600.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31039374..31046821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260449.2 → NP_001247378.2  calcineurin A1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247378.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48456, Q8MQN3, Q9TY69, Q9VA20
      UniProtKB/TrEMBL
      A0A0B4K6V6
      Conserved Domains (2) summary
      smart00156
      Location:98 → 369
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:81 → 385
      MPP_PP2B; PP2B, metallophosphatase domain

    2. NM_079861.4 → NP_524600.3  calcineurin A1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524600.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48456, Q8MQN3, Q9TY69, Q9VA20
      UniProtKB/TrEMBL
      A0A0B4K6V6
      Related
      FBpp0085094
      Conserved Domains (2) summary
      smart00156
      Location:98 → 369
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:81 → 385
      MPP_PP2B; PP2B, metallophosphatase domain

    3. NM_001260448.2 → NP_001247377.1  calcineurin A1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6N5
      Conserved Domains (2) summary
      smart00156
      Location:98 → 369
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:81 → 385
      MPP_PP2B; PP2B, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6N5 A0A0B4K6N5
    A0A0B4K6V6 A0A0B4K6V6
    P48456.2 P48456

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