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    Rx Retinal Homeobox [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37367, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rxprovided by FlyBase
    Official Full Name
    Retinal Homeoboxprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020617
    Locus tag
    Dmel_CG10052
    See related
    AllianceGenome:FB:FBgn0020617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bk50; CG10052; Dmel\CG10052; drx; Drx; DRx; E97; PPH17; rx; W60; wom
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; brain; imaginal disc primordium; mushroom body; and neuroblasts. Human ortholog(s) of this gene implicated in age related macular degeneration 6; cone-rod dystrophy 11; isolated microphthalmia 3; and retinitis pigmentosa. Orthologous to human RAX (retina and anterior neural fold homeobox) and RAX2 (retina and anterior neural fold homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    57B4-57B4; 2-92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20916753..20937030)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16804258..16824535)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene orthopedia Neighboring gene antisense RNA:CR43160 Neighboring gene Carbonic anhydrase 15 Neighboring gene ncRNA Neighboring gene Actin 57B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence heterochrony led to a gain of functionality in an immature stage of the central complex: A fly-beetle insight. Farnworth MS, et al. PLoS Biol, 2020 Oct. PMID 33104689, Free PMC Article
    2. Functional analysis of enhancer elements regulating the expression of the Drosophila homeodomain transcription factor DRx by gene targeting. Klöppel C, et al. Hereditas, 2021 Nov 5. PMID 34736520, Free PMC Article
    3. Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development. Eggert T, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482887, Free PMC Article
    4. Identification of enhancers that drive the spatially restricted expression of Vsx1 and Rx in the outer proliferation center of the developing Drosophila optic lobe. Islam IM, et al. Genome, 2021 Feb. PMID 33054400
    5. The Rx homeobox gene is essential for vertebrate eye development. Mathers PH, et al. Nature, 1997 Jun 5. PMID 9177348

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis of enhancer elements regulating the expression of the Drosophila homeodomain transcription factor DRx by gene targeting.
      Title: Functional analysis of enhancer elements regulating the expression of the Drosophila homeodomain transcription factor DRx by gene targeting.
    2. Identification of enhancers that drive the spatially restricted expression of Vsx1 and Rx in the outer proliferation center of the developing Drosophila optic lobe.
      Title: Identification of enhancers that drive the spatially restricted expression of Vsx1 and Rx in the outer proliferation center of the developing Drosophila optic lobe.
    3. We then show that Rx controls proliferation within the MBNB clones independently of Tailless (Tll) and Prospero (Pros), and does not regulate the expression of other key regulators of MB development, Eyeless (Ey) and Dachshund (Dac). Our data support that the role of Rx in forebrain development is conserved between vertebrates and fly.
      Title: Retinal homeobox promotes cell growth, proliferation and survival of mushroom body neuroblasts in the Drosophila brain.
    4. Drx is not required for establishment of the drosophila visual system.
      Title: Drosophila retinal homeobox (drx) is not required for establishment of the visual system, but is required for brain and clypeus development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinal homeobox
    Names
    CG10052-PB
    Rx-PB
    drosophila Rx
    wombat
    NP_726006.3
    • frameshift

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20916753..20937030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166413.3 → NP_726006.3  retinal homeobox [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726006.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46035, Q9W2Q1
      Conserved Domains (2) summary
      pfam00046
      Location:563 → 615
      Homeobox; Homeobox domain
      pfam03826
      Location:876 → 892
      OAR; OAR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2Q1.2 Q9W2Q1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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