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    Cad96Ca Cadherin 96Ca [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cad96Caprovided by FlyBase
    Official Full Name
    Cadherin 96Caprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022800
    Locus tag
    Dmel_CG10244
    See related
    AllianceGenome:FB:FBgn0022800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cad 96Ca; cad96C; Cad96C; cad96Ca; CG10239; CG10244; CT28779; DCad96Ca; Dm Cad96Ca; Dmel\CG10244; DmHD-14; FGFR1-like; HD-14; stit
    Summary
    Enables protein tyrosine kinase activity. Involved in several processes, including negative regulation of cell size; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of wound healing. Located in apical part of cell. Is expressed in several structures, including adult tracheal system; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Cad96Ca in Genome Data Viewer
    Location:
    96C4-96C5; 3-87 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25197571..25208283, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21023293..21034005, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lost boys Neighboring gene distal antenna Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PDZ-domain-binding sites are common among cadherins. Demontis F, et al. Dev Genes Evol, 2006 Nov. PMID 17021864
    2. Analysis of the Molecular Mechanisms of Reepithelialization in Drosophila Embryos. Matsubayashi Y, et al. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274434, Free PMC Article
    3. Src kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila. Tsarouhas V, et al. J Cell Sci, 2014 Apr 15. PMID 24522188
    4. The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila. Wang S, et al. Nat Cell Biol, 2009 Jul. PMID 19525935
    5. Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher. O'Farrell F, et al. PLoS Biol, 2013 Jul. PMID 23935447, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ret-like receptor tyrosine kinase Stitcher regulates both re-epithelialization and transcriptional activation by Grainy head to induce restoration of the extracellular barrier.
      Title: Src kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila.
    2. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
      Title: Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher.
    3. Daya identified stitcher (stit, CG10244), a new Grh target and show that Stit activation upon wounding coordinates cytoskeletal rearrangements and the level of Grh-mediated transcriptional wound responses.
      Title: The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in wound healing IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cadherin 96Ca
    Names
    CG10244-PA
    Cad96Ca-PA
    stitcher
    NP_651349.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25197571..25208283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143092.3 → NP_651349.1  cadherin 96Ca [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18368, Q8SZC9, Q9VBW2, Q9VBW3
      Related
      FBpp0084248
      Conserved Domains (3) summary
      cd11304
      Location:65 → 164
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00221
      Location:470 → 741
      STYKc; Protein kinase; unclassified specificity
      cd00192
      Location:474 → 742
      PTKc; Catalytic domain of Protein Tyrosine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBW3.2 Q9VBW3

    Gene LinkOut

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