Nmdar2 NMDA receptor 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nmdar2provided by FlyBase
Official Full Name: NMDA receptor 2provided by FlyBase
Primary source: FLYBASE:FBgn0053513
Locus tag: Dmel_CG33513
See related: AllianceGenome:FB:FBgn0053513
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 79G8T; anon-sts34; CG14793; CG14794; CG33513; CT34603; DmelNmdar2; Dmel\CG33513; dnmdar-II; dNR2; DrNR2; dsNR2; EG:80H7.7; ESTS:79G8T; NMDA-R2; NMDAR; nmdar2; NmdaR2; NMDAR2; nr2; NR2
Summary: Contributes to NMDA glutamate receptor activity. Involved in ionotropic glutamate receptor signaling pathway; memory; and sensory perception of touch. Located in membrane. Part of ionotropic glutamate receptor complex. Is expressed in several structures, including adult brain; adult ellipsoid body ring neuron R4m; adult head; calyx of adult mushroom body; and larval central nervous system. Used to study developmental disorder of mental health and epilepsy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 2B1-2B1; 1-0.2 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1483625..1507809, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1377658..1401842, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMDA Receptor 2 plays a role in both behavioral responses to touch and in the formation of the actin-rich sensory filopodia.
Title: Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae.
Distribution of the NR2 subunit of the NMDA receptor in the cerebral ganglia of the honeybee and fruit fly are similar; areas with the highest concentrations of NR2 subunits were identified and compared.
Title: Comparative analysis of the locations of the NR1 and NR2 NMDA receptor subunits in honeybee (Apis mellifera) and fruit fly (Drosophila melanogaster, Canton-S wild-type) cerebral ganglia.
nmda receptor 2 regiure for long-term memory consolidation in Drosophila ellipsoid body.
Title: Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in long-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ionotropic glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NMDA receptor 2

Names: CG33513-PA; CG33513-PB; CG33513-PC; CG33513-PD; CG33513-PE; CG33513-PF; CG33513-PG; NMDA receptor; Nmdar2-PA; Nmdar2-PB; Nmdar2-PC; Nmdar2-PD; Nmdar2-PE; Nmdar2-PF; Nmdar2-PG; dNR2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

1483625..1507809 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297859.1 → NP_001284788.1 NMDA receptor 2, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284788.1

Status: REVIEWED

UniProtKB/TrEMBL

O76903, X2JDW0

Conserved Domains (3) summary

cd06378
Location:99 → 490

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cd13718
Location:502 → 908

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:665 → 928

Lig_chan; Ligand-gated ion channel
NM_001014715.2 → NP_001014715.1 NMDA receptor 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014715.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MM14, Q8MX77

Conserved Domains (2) summary

cd06378
Location:1 → 309

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cd13718
Location:321 → 727

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
NM_001014714.2 → NP_001014714.1 NMDA receptor 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014714.1

Status: REVIEWED

UniProtKB/TrEMBL

O76903, Q6IWN8, Q9W581

Conserved Domains (3) summary

cd06378
Location:99 → 490

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cd13718
Location:502 → 908

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:665 → 928

Lig_chan; Ligand-gated ion channel
NM_001169164.1 → NP_001162635.1 NMDA receptor 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162635.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MM14, Q8MX77

Conserved Domains (2) summary

cd06378
Location:1 → 309

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cd13718
Location:321 → 727

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
NM_001014716.2 → NP_001014716.1 NMDA receptor 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014716.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MM14, Q8MX77

Conserved Domains (2) summary

cd06378
Location:1 → 309

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cd13718
Location:321 → 727

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
NM_001169165.1 → NP_001162636.1 NMDA receptor 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162636.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJC6, Q8MX77

Conserved Domains (3) summary

cd06378
Location:21 → 348

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cd13718
Location:360 → 766

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:523 → 786

Lig_chan; Ligand-gated ion channel
NM_001169166.1 → NP_001162637.1 NMDA receptor 2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162637.1

Status: REVIEWED

UniProtKB/TrEMBL

O76903, Q6IWN7

Conserved Domains (3) summary

cd06378
Location:99 → 490

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cd13718
Location:502 → 908

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:665 → 928

Lig_chan; Ligand-gated ion channel