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    pon partner of numb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ponprovided by FlyBase
    Official Full Name
    partner of numbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025739
    Locus tag
    Dmel_CG3346
    See related
    AllianceGenome:FB:FBgn0025739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3346; Dmel\CG3346; Pon; PON
    Summary
    Involved in embryonic heart tube development. Located in cell cortex. Is expressed in imaginal disc and somatic precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pon in Genome Data Viewer
    Location:
    4C10-4C10; 1-8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4636318..4639112)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4530351..4533145)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Alstrom syndrome 1b Neighboring gene Alstrom syndrome 1a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Helix loop helix protein 4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunofluorescent labeling of neural stem cells in the Drosophila optic lobe. Perruchoud B, et al. Methods Mol Biol, 2014. PMID 24048927
    2. Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity. Zhu K, et al. Structure, 2016 Jul 6. PMID 27238966
    3. Abstrakt, a DEAD box protein, regulates Insc levels and asymmetric division of neural and mesodermal progenitors. Irion U, et al. Curr Biol, 2004 Jan 20. PMID 14738736
    4. Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division. Lu B, et al. Mol Cell, 1999 Dec. PMID 10635314
    5. Long-term live cell imaging and automated 4D analysis of drosophila neuroblast lineages. Homem CC, et al. PLoS One, 2013. PMID 24260257, Free PMC Article

    See all (167) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. condensed Numb and Pon complex has roles in phase transition during Drosophila neuroblast asymmetric division
      Title: Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
    2. Pon overexpression alters polar protein distribution is relevant because Pon is often used as a polarity marker in dividing progenitors.
      Title: Overexpression of partner of numb induces asymmetric distribution of the PI4P 5-Kinase Skittles in mitotic sensory organ precursor cells in Drosophila.
    3. Polo directly phosphorylates Partner of Numb (Pon), an adaptor protein for Numb, and this phosphorylation event is important for Pon to localize Numb
      Title: Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.
    4. Numb and Pon rapidly exchange between a cytoplasmic pool and the cell cortex and that preferential recruitment from the cytoplasm is responsible for their asymmetric distribution during mitosis.
      Title: Quantitative analysis of protein dynamics during asymmetric cell division.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in embryonic heart tube development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    partner of numb
    Names
    CG3346-PA
    pon-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4636318..4639112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080333.3 → NP_525072.2  partner of numb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525072.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96561, Q9W4I7
      Related
      FBpp0070649
      Conserved Domains (2) summary
      cd16269
      Location:435 → 445
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:358 → 445
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96561 O96561
    Q9W4I7 Q9W4I7

    Gene LinkOut

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